ArticleMolecular psychiatry2021
Disease trajectories and mortality among individuals diagnosed with depression: a community-based cohort study in UK Biobank.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 94 citations in OpenAlex.
- Examining glycation as a mediator linking bullying to psychotic experience and depressive symptom in adolescents.Molecular psychiatry · 2026Article
- Chronotype, Genetic Risk, Lifestyle, and Risk of Depression and Anxiety: A Prospective Cohort Study.MedComm · 2026Article
- Major depressive disorder (MDD) and the risks of mortality and hospitalization in the UK Biobank.BMC psychiatry · 2026Article
- Metabolic syndromes mediate the association between depression and cardiovascular diseases in the UK Biobank Population Study.Comprehensive psychoneuroendocrinology · 2026Article
- Depressive symptom trajectories and the association with diabetes and cardiovascular diseases in middle-aged and older Chinese adults: a cohort study.BMC public health · 2026Article
- Metabolomic dysregulation in the association between major depressive disorder and chronic pancreatitis: a large prospective cohort study.Frontiers in nutrition · 2026Article
- Resources and applications of public biomedical data.Frontiers in bioinformatics · 2026Review
- Association of inflammatory bowel disease with cardiovascular disease, and the mediating role of inflammation: a matched-cohort study.Therapeutic advances in gastroenterology · 2026Article
- Mental health status and cardiovascular outcomes across Life's Essential 8 categories.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Investigating multimorbidity trajectories in people living with MASLD diagnosis: A trajectory analysis using the UK Biobank.Diabetes, obesity & metabolism · 2025Article
- Disease clusters and death trajectories in individuals with frailty: a prospective cohort study from the UK Biobank.BMC public health · 2025Article
- Disease clusters and their genetic determinants following a diagnosis of depression: analyses based on a novel three-dimensional disease network approach.Molecular psychiatry · 2025Article
- Disease trajectory and mortality among sepsis patients: a prospective cohort study.BMC infectious diseases · 2025Article
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank.Annals of clinical and translational neurology · 2025Article
- Exploring population and sex-specific disease trajectories for multimorbidities among individuals with overweight or obesity: A retrospective cohort study in UK biobank.Diabetes, obesity & metabolism · 2025Article
- Association Between Trajectories of Depressive Symptoms and Cardiovascular Disease in Elderly Chinese Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS).Brain and behavior · 2025Article
- Disease and mortality trajectories of cognitively able autistic individuals in mid- and later adulthood.BMC medicine · 2025Article
- Disease trajectories and medical expenditures of older adults with disabilities: insights from China's long-term care insurance program.BMC geriatrics · 2025Article
- Increased risk of multisystem comorbidities and disease trajectories following hyperthyroidism: evidence from the 0.5 million UK Biobank population.Endocrine connections · 2025Article
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Authors and funding
14 authors at 5 institutions in 4 countries.
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Abstract
Patients with depression are at increased risk for a range of comorbid diseases, with, however, unclear explanations. In this large community-based cohort study of the UK Biobank, 24,130 patients diagnosed with depression were compared to 120,366 matched individuals without such a diagnosis. Follow-up was conducted from 6 months after the index date until death or the end of 2019, for the occurrence of 470 medical conditions and 16 specific causes of death. The median age at the time of the depression diagnosis was 62.0 years, and most of the patients were female (63.63%). During a median follow-up of 4.94 years, 129 medical conditions were found to be significantly associated with a prior diagnosis of depression, based on adjusted Cox regression models. Using disease trajectory network analysis to visualize the magnitude of disease-disease associations and the temporal order of the associated medical conditions, we identified three main affected disease clusters after depression (i.e., cardiometabolic diseases, chronic inflammatory diseases, and diseases related to tobacco abuse), which were further linked to a wider range of other conditions. In addition, we also identified three depression-mortality trajectories leading to death due to cardiovascular disease, respiratory system disease and malignant neoplasm. In conclusion, an inpatient diagnosis of depression in later life is associated with three distinct network-based clusters of medical conditions, indicating alterations in the cardiometabolic system, chronic status of inflammation, and tobacco abuse as key pathways to a wide range of other conditions downstream. If replicated, these pathways may constitute promising targets for the health promotion among depression patients.
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