Evidence map›Paper›PMID 34035475›Full record

ArticleMolecular psychiatry2021

White matter abnormalities associated with ADHD outcomes in adulthood.

A Versace, N P Jones, H M Joseph, R A Lindstrom, T K Wilson, J P Lima Santos, E M Gnagy, W E Pelham, C D Ladouceur, B S G Molina

Open access · greenAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The structural connectome in ADHD.Psychoradiology · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

A VersaceDepartment of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. versacea@upmc.edu.ORCID http://orcid.org/0000-0001-9925-5203
N P JonesDepartment of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
H M JosephDepartment of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
R A LindstromUniversity of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA.
T K WilsonUniversity of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA.
J P Lima SantosDepartment of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-0676-8515
E M GnagyDepartment of Psychology, Florida International University, Miami, FL, USA.
W E PelhamDepartment of Psychology, Florida International University, Miami, FL, USA.
C D Ladouceur *Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-4816-0997
B S G Molina *Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7574-3755
University of Pittsburgh · USFlorida International University · USUniversity of Pittsburgh Medical Center · US

Funding

DEVELOPMENT OF ALCOHOL USE AND ABUSE IN ADHD ADOLESCENTSR01AA011873 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 1998 to 2007
$8.5M
The Development of Alcohol Use and Abuse in ADHD Adolescents and Young AdultsR37AA011873 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2008 to 2017
$7.9M
INTERDISCIPLINARY ALCOHOL RESEARCH TRAINING PROGRAMT32AA007453 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKE S.G. MOLINA · 1985 to 2026
$3.7M
Neural correlates of adult outcomes of childhood ADHD: Affect, reward and controlR01MH101096 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LADOUCEUR, CECILE D., MOLINA, BROOKE S.G. · 2014 to 2018
$3.0M
Development of Drug Use and Abuse in ADHD AdolescentsR01DA012414 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PELHAM, WILLIAM E · 2001 to 2012
$2.2M
The Pittsburgh ADHD Longitudinal Study: Predicting alcohol misuse, problems, and disorder in mid-adulthoodR56AA011873 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2018 to 2018
$100k
NIAAA NIH HHS R01 AA011873NIAAA NIH HHS R37 AA011873NIAAA NIH HHS R56 AA011873NIAAA NIH HHS T32 AA007453NIDA NIH HHS R01 DA012414NIMH NIH HHS R01 MH101096
6 · The paper itself

Abstract

It remains unclear if previously reported structural abnormalities in children with ADHD are present in adulthood regardless of clinical outcome. In this study, we examined the extent to which focal-rather than diffuse-abnormalities in fiber collinearity of 18 major white matter tracts could distinguish 126 adults with rigorously diagnosed childhood ADHD (ADHD; mean age [SD] = 34.3 [3.6] years; F/M = 12/114) from 58 adults without ADHD histories (non-ADHD; mean age [SD] = 33.9 [4.1] years; F/M = 5/53) and if any of these abnormalities were greater for those with persisting ADHD symptomatology. To this end, a tract profile approach was used. After accounting for age, sex, handedness, and comorbidities, a MANCOVA revealed a main effect of group (ADHD < non-ADHD; F

Indexed as

Attention Deficit Disorder with HyperactivityWhite MatterAdultAnisotropyBrainChildChild, PreschoolDiffusion Tensor ImagingHumansNerve Net

Identifiers

PMID34035475
PMCPMC8613296
OpenAlexW3164109277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.