Evidence map›Paper›PMID 34035457›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2021

Response to first dose of inhaled albuterol in mechanically ventilated preterm infants.

Thomas M Raffay, Mandy Brasher, Brooke C Place, Abhijit Patwardhan, Peter J Giannone, Henrietta Bada, Philip M Westgate, Elie G Abu Jawdeh

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thomas M RaffayPediatrics/Neonatology, UH Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-6572-8719
Mandy BrasherPediatrics/Neonatology, University of Kentucky, Lexington, KY, USA.
Brooke C PlaceBiomedical Engineering, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0001-6247-3661
Abhijit PatwardhanBiomedical Engineering, University of Kentucky, Lexington, KY, USA.
Peter J GiannonePediatrics/Neonatology, University of Kentucky, Lexington, KY, USA.
Henrietta BadaPediatrics/Neonatology, University of Kentucky, Lexington, KY, USA.
Philip M WestgateBiostatistics, University of Kentucky, Lexington, KY, USA. philip.westgate@uky.edu.
Elie G Abu JawdehPediatrics/Neonatology, University of Kentucky, Lexington, KY, USA. elie.abujawdeh@uky.edu.ORCID http://orcid.org/0000-0003-4414-7007
University of Kentucky · USRainbow Babies & Children's Hospital · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
KENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR033173 · NCRR · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2011 to 2011
$3.5M
S-nitrosoglutathione reductase and airways hyperreactivity in murine bronchopulmonary dysplasiaK08HL133459 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI RAFFAY, THOMAS MICHAEL · 2017 to 2021
$821k
Pilot Study of an Inhaled Treatment for Bronchopulmonary DysplasiaR03HL155246 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI RAFFAY, THOMAS MICHAEL · 2021 to 2022
$140k
NCATS NIH HHS UL1 TR001998NCRR NIH HHS UL1 RR033173NHLBI NIH HHS K08 HL133459NHLBI NIH HHS R03 HL155246
6 · The paper itself

Abstract

backgroundBronchodilator responses among preterm infants are heterogeneous. Bedside measurements may identify responders. STUDY

designRespiratory measurements (Resistance, Compliance, FiO

resultsMedian gestation and birthweight were 25 3/7 weeks and 730 g, respectively. Mean Resistance decreased post-albuterol (p = 0.007). Sixty-eight percent of infants were responders based on decreased Resistance. Compliance and FiO

conclusionsVentilator resistance decreased in two-thirds of preterm infants, consistent with studies that utilized formal pulmonary function testing. Albuterol had a variable effect on delivered FiO

Indexed as

AlbuterolRespiration, ArtificialBronchodilator AgentsHumansInfantInfant, NewbornInfant, PrematureOximetryAlbuterolBronchodilator Agents

Identifiers

PMID34035457
PMCPMC8147907
OpenAlexW3163989135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.