Evidence map›Paper›PMID 34035435›Full record

Trial reportBritish journal of cancer2021

New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer.

Jayant S Vaidya, Max Bulsara, Michael Baum, Frederik Wenz, Samuele Massarut, Steffi Pigorsch, Michael Alvarado, Michael Douek, Christobel Saunders, Henrik Flyger and 29 more

Registry-linked trialOpen access · hybridAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00983684 (TARGIT), which is not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00983684 phase3completednot on this map

TARGIT: A Randomised Controlled Trial to Compare Targeted Intra-operative Radiotherapy With Conventional Post-operative Radiotherapy After Conservative Breast Surgery for Women With Early Stage Breast Cancer

TypeinterventionalSponsorUniversity College, LondonRan2000 to 2012Enrolled3,451ConditionsInvasive Breast Cancer, Breast CancerArmsIntrabeam, Post-operative radiotherapy
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Prospects and Disadvantages of Intraoperative Radiotherapy: A Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2025
    Pooled it
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  9. Review
  10. The evolution of targeted intra operative radiotherapy in early breast cancer.Journal of cancer research and clinical oncology · 2025
    Review
  11. Sustainability in radiation oncology: opportunities for enhancing patient care and reducing COStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Article
  12. Intraoperative radiation therapy (IORT) in Taiwanese breast cancer patients: factors influencing local relapse risk and disease-free survival.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Article
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 20 institutions in 11 countries.

Jayant S VaidyaDivision of Surgery and Interventional Science, University College London, London, UK. jayantvaidya@gmail.com.ORCID http://orcid.org/0000-0003-1760-1278
Max BulsaraDepartment of Biostatistics, University of Notre Dame, Fremantle, WA, Australia.
Michael BaumDivision of Surgery and Interventional Science, University College London, London, UK.
Frederik WenzDepartment of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Samuele MassarutDepartment of Surgery, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Steffi PigorschDepartment of Radiation Oncology, Red Cross Hospital, Technical University of Munich, Munich, Germany.
Michael AlvaradoDepartment of Surgery, University of California, San Francisco, CA, USA.
Michael DouekNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Christobel SaundersSchool of Surgery, University of Western Australia, Perth, WA, Australia.
Henrik FlygerDepartment of Breast Surgery, University of Copenhagen, Copenhagen, Denmark.
Wolfgang EiermannDepartment of Gynecology and Obstetrics, Red Cross Hospital, Technical University of Munich, Munich, Germany.
Chris Brew-GravesDivision of Surgery and Interventional Science, University College London, London, UK.
Norman R WilliamsDivision of Surgery and Interventional Science, University College London, London, UK.
Ingrid PotykaDivision of Surgery and Interventional Science, University College London, London, UK.
Nicholas RobertsDivision of Surgery and Interventional Science, University College London, London, UK.
Marcelle BernsteinPatient advocate and writer, London, UK.
Douglas BrownDepartment of Surgery, Ninewells Hospital, Dundee, UK.
Elena SperkDepartment of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Siobhan LawsDepartment of Surgery, Royal Hampshire County Hospital, Winchester, UK.
Marc SütterlinDepartment of Gynecology and Obstetrics, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Berlin, Germany.
Tammy CoricaDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Steinar LundgrenDepartment of Oncology, St Olav's University Hospital, & Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Dennis HolmesJohn Wayne Cancer Institute & Helen Rey Breast Cancer Foundation, University of Southern California, Los Angeles, CA, USA.
Lorenzo VinanteDepartment of Radiation Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Fernando BozzaDepartment of Surgery, Instituto Oncologico Veneto (IVO) IRCCS, Padoa, Italy.
Montserrat PazosDepartment of Radiation Oncology, University Hospital, Ludwig Maximilians Universitat, Munich, Germany.
Magali Le Blanc-OnfroyOncologie radiothérapeute, Institut de Cancérologie de l'Ouest, Nantes, France.
Günther GruberBrust Zentrum Seefeld, Zurich, Switzerland.
Wojciech PolkowskiDepartment of Surgical Oncology, Medical University of Lublin, Lublin, Poland.
Konstantin J DedesBreast Center, Universitätsspital Zürich, Zurich, Switzerland.
Marcus NiewaldSaarland University Medical Center, Homburg, Germany.
Jens BlohmerSankt Gertrauden-Krankenhaus, and The Charité-Universitätsmedizin Berlin, Berlin, Germany.
David McReadyPrincess Margaret Cancer Centre, Toronto, Canada.
Richard HoeferSentara Surgery Specialists, Hampton, VA, USA.
Pond KelemenAshikari Breast Center, New York Medical College, New York, NY, USA.
Gloria PetraliaDepartment of Surgery, University College London Hospitals, London, UK.
Mary FalzonDepartment of Pathology University College London Hospitals, London, UK.
David JosephDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Jeffrey S TobiasDepartment of Clinical Oncology, University College London Hospitals, London, UK.
University College London · GBHeidelberg University · DERoyal London Hospital · GBCentro di Riferimento Oncologico · ITKrankenhaus vom Roten Kreuz · DESir Charles Gairdner Hospital · AUImmunologie-Zentrum Zürich · CHInstitut de Cancérologie de l'Ouest · FRIstituto Oncologico Veneto · ITLudwig-Maximilians-Universität München · DEMedical University of Lublin · PLNew York Medical College · USNinewells Hospital · GBNorwegian University of Science and Technology · NOPrincess Margaret Cancer Centre · CARoyal Hampshire County Hospital · GBSaarland University · DESankt Gertrauden Krankenhaus · DEThe Patients Association · GBThe University of Notre Dame Australia · AU

Funding

Department of Health 07/60/49Department of Health 10/104/07Department of Health 14/49/13
6 · The paper itself

Abstract

backgroundThe TARGIT-A trial reported risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy for breast cancer to be as effective as whole-breast external beam radiotherapy (EBRT). Here, we present further detailed analyses.

methodsIn total, 2298 women (≥45 years, invasive ductal carcinoma ≤3.5 cm, cN0-N1) were randomised. We investigated the impact of tumour size, grade, ER, PgR, HER2 and lymph node status on local recurrence-free survival, and of local recurrence on distant relapse and mortality. We analysed the predictive factors for recommending supplemental EBRT after TARGIT-IORT as part of the risk-adapted approach, using regression modelling. Non-breast cancer mortality was compared between TARGIT-IORT plus EBRT vs. EBRT.

resultsLocal recurrence-free survival was no different between TARGIT-IORT and EBRT, in every tumour subgroup. Unlike in the EBRT arm, local recurrence in the TARGIT-IORT arm was not a predictor of a higher risk of distant relapse or death. Our new predictive tool for recommending supplemental EBRT after TARGIT-IORT is at https://targit.org.uk/addrt . Non-breast cancer mortality was significantly lower in the TARGIT-IORT arm, even when patients received supplemental EBRT, HR 0.38 (95% CI 0.17-0.88) P = 0.0091.

conclusionTARGIT-IORT is as effective as EBRT in all subgroups. Local recurrence after TARGIT-IORT, unlike after EBRT, has a good prognosis. TARGIT-IORT might have a beneficial abscopal effect.

trial registrationISRCTN34086741 (21/7/2004), NCT00983684 (24/9/2009).

Indexed as

AgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCombined Modality TherapyFemaleHumansIntraoperative CareMastectomy, SegmentalMiddle AgedPrognosisSurvival AnalysisTreatment OutcomeTumor BurdenWhole-Body Irradiation

Identifiers

PMID34035435
PMCPMC8329051
OpenAlexW3164978296

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.