Evidence map›Paper›PMID 34035349›Full record

ArticleScientific reports2021

Modular barcode beads for microfluidic single cell genomics.

Cyrille L Delley, Adam R Abate

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Optics-free reconstruction of 2D images via DNA barcode proximity graphs.bioRxiv : the preprint server for biology · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cyrille L DelleyBioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94158, USA.
Adam R AbateBioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94158, USA. adam@abatelab.org.

Funding

Gigapixel digital PCR in Giant Unilamellar VesiclesR01EB019453 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R., CHIU, CHARLES YEN · 2014 to 2022
$3.9M
Microfluidic immunoprofiling for biomarker discovery in rheumatoid arthritisDP2AR068129 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R. · 2014 to 2014
$2.4M
Accurate and unbiased single cell sequencing with digital droplet MDAR01HG008978 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R. · 2016 to 2018
$1.9M
National Science Foundation CAREER Award DBI-1253293NHGRI NIH HHS R01 HG008978NHGRI NIH HHS R01-HG008978NIAMS NIH HHS DP2 AR068129NIAMS NIH HHS DP2-AR068129-01NIBIB NIH HHS R01 EB019453NIBIB NIH HHS R01-EB019453-01Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 183853
6 · The paper itself

Abstract

Barcode beads allow efficient nucleic acid tagging in single cell genomics. Current barcode designs, however, are fabricated with a particular application in mind. Repurposing to novel targets, or altering to add additional targets as information is obtained is possible but the result is suboptimal. Here, we describe a modular framework that simplifies generation of multifunctional beads and allows their easy extension to new targets.

Indexed as

Biomarkers, TumorDNA Barcoding, TaxonomicGene Expression ProfilingGene Expression Regulation, NeoplasticGenomicsHumansMicrofluidicsNeoplasmsSingle-Cell AnalysisTranscriptomeBiomarkers, Tumor

Identifiers

PMID34035349
PMCPMC8149635

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.