ArticleScientific reports2021
Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Applications of elastography in operative neurosurgery: A systematic review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022Pooled it
- Arterial spin labeling MRI with multiple post-labeling delays reveals interictal hypo- and hyper-perfusion patterns in epilepsy: A proof of concept.Journal of neuroradiology = Journal de neuroradiologie · 2026Article
- Network-guided resection of magnetic resonance imaging-negative mesial temporal epilepsy using gamma oscillation regularity-based transfer entropy analysis.Surgical neurology international · 2026Article
- Multimodal Imaging in Epilepsy Surgery for Personalized Neurosurgical Planning.Journal of personalized medicine · 2025Review
- Review
- Does arterial spin labelling represent a valid alternative to other MR perfusion techniques in neuro-oncology?La Radiologia medica · 2025Review
- Visualizing epileptogenic regions using the chemical exchange saturation transfer method in a patient with drug-resistant focal epilepsy: a case report.Journal of medical case reports · 2025Article
- Lateralizing Value of Artificial Intelligence-Based Segmentation Software in MRI-Negative Focal Epilepsy.Journal of epilepsy research · 2024Article
- Augmented Reality in Extratemporal Lobe Epilepsy Surgery.Journal of clinical medicine · 2024Article
- Magnetic resonance imaging in canine idiopathic epilepsy: a mini-review.Frontiers in veterinary science · 2024Review
- Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging.Magnetic resonance in medicine · 2023Article
- Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy.Scientific reports · 2022Article
- Comparison of Qualitative and Quantitative Analyses of MR-Arterial Spin Labeling Perfusion Data for the Assessment of Pediatric Patients with Focal Epilepsies.Diagnostics (Basel, Switzerland) · 2022Article
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Authors and funding
7 authors.
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Abstract
Drug-resistant epilepsy is a diagnostic and therapeutic challenge, mainly in patients with negative MRI findings. State-of-the-art imaging methods complement standard epilepsy protocols with new information and help epileptologists to increase the reliability of their decisions. In this study, we investigate whether arterial spin labeling (ASL) perfusion MRI can help localize the epileptogenic zone (EZ). To that end, we developed an image processing method to detect the EZ as an area with hypoperfusion relative to the contralateral unaffected side, using subject-specific thresholding of the asymmetry index in ASL images. We demonstrated three thresholding criteria (termed minimal product criterion, minimal distance criterion, and elbow criterion) on 29 patients with MRI-negative epilepsy (age 32.98 ± 10.4 years). The minimal product criterion showed optimal results in terms of positive predictive value (mean 0.12 in postoperative group and 0.22 in preoperative group) and true positive rate (mean 0.71 in postoperative group and 1.82 in preoperative group). Additionally, we found high accuracy in determining the EZ side (mean 0.86 in postoperative group and 0.73 in preoperative group out of 1.00). ASL can be easily incorporated into the standard presurgical MR protocol, and it provides an additional benefit in EZ localization.
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