ArticleNature communications2021
Cellular lensing and near infrared fluorescent nanosensor arrays to enable chemical efflux cytometry.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Structural, Compositional, and Dielectric State Profiling in Label-Free Single-Cell Monitoring.Small methods · 2026Review
- Chemical efflux imaging using an annular nanosensor array for in situ bladder cancer detection.Nature nanotechnology · 2026Article
- Label-free and real-time monitoring of photoaging with high spatiotemporal resolution using an nIR fluorescent nanosensor array.Science advances · 2025Article
- Unveiling aging heterogeneities in human dermal fibroblasts via nanosensor chemical cytometry.Nature communications · 2025Article
- Spatiotemporal molecular tracing of ultralow-volume biofluids via a soft skin-adaptive optical monolithic patch sensor.Nature communications · 2025Article
- Cytometry in the Short-Wave Infrared.ACS nano · 2024Article
- Monitoring Enzyme Activity Using Near-Infrared Fluorescent Single-Walled Carbon Nanotubes.ACS sensors · 2024Review
- Finding intracellular lipid droplets from the single-cell biolens' signature in a holographic flow-cytometry assay.Biomedical optics express · 2022Article
- Prospects of NIR fluorescent nanosensors for green detection of SARS-CoV-2.Sensors and actuators. B, Chemical · 2022Review
- Lipid droplets as endogenous intracellular microlenses.Light, science & applications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanosensors have proven to be powerful tools to monitor single cells, achieving spatiotemporal precision even at molecular level. However, there has not been way of extending this approach to statistically relevant numbers of living cells. Herein, we design and fabricate nanosensor array in microfluidics that addresses this limitation, creating a Nanosensor Chemical Cytometry (NCC). nIR fluorescent carbon nanotube array is integrated along microfluidic channel through which flowing cells is guided. We can utilize the flowing cell itself as highly informative Gaussian lenses projecting nIR profiles and extract rich information. This unique biophotonic waveguide allows for quantified cross-correlation of biomolecular information with various physical properties and creates label-free chemical cytometer for cellular heterogeneity measurement. As an example, the NCC can profile the immune heterogeneities of human monocyte populations at attomolar sensitivity in completely non-destructive and real-time manner with rate of ~600 cells/hr, highest range demonstrated to date for state-of-the-art chemical cytometry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.