ArticleNature communications2021
Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Longitudinal alignments and syntheses of multimodal clinical data for personalized medicine with the PULSE framework.Nature computational science · 2026Article
- From aging biology to cardiac biotechnology: emerging platforms for modeling cardiac aging.JCI insight · 2026Review
- Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026Review
- A large cohort analysis of metabolic signatures underlying the liver-eye axis.Communications medicine · 2026Article
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- Aspiration to architecture: multi-omics, AI, digital twins, and blockchain for P4 medicine.Journal of translational medicine · 2026Article
- Latent biochemical phenotypes delineate divergent health trajectories in older adults.npj aging · 2026Article
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- Biological evidence of the life expectancy limit in human aging.GeroScience · 2026Article
- Artificial intelligence approaches in biological age prediction: current status and challenges.British journal of biomedical science · 2026Review
- Nurses as guardians of time: the hidden clinical value of continuous care in geriatrics.Frontiers in public health · 2026Review
- Microgravity Therapy as Treatment for Decelerated Aging and Successful Longevity.International journal of molecular sciences · 2025Review
- Article
- Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts.Nature communications · 2025Article
- Identifying central symptom clusters and correlates among post-COVID-19 pulmonary fibrosis patients: a network analysis.Frontiers in medicine · 2025Article
- Recent progress in stem cell and immune cell-based interventions for aging and age-related disorders.Frontiers in aging · 2025Review
- Estimation of physiological aging based on routine clinical biomarkers: a prospective cohort study in elderly Chinese and the UK Biobank.BMC medicine · 2024Article
- Dynamical Network Stability Analysis of Multiple Biological Ages Provides a Framework for Understanding the Aging Process.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Health outcomes of COVID-19 patients from Wuhan, China 3-year after hospital discharge: a cohort study.BMJ open · 2024Observational
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We investigated the dynamic properties of the organism state fluctuations along individual aging trajectories in a large longitudinal database of CBC measurements from a consumer diagnostics laboratory. To simplify the analysis, we used a log-linear mortality estimate from the CBC variables as a single quantitative measure of the aging process, henceforth referred to as dynamic organism state indicator (DOSI). We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120 - 150 years of age corresponding to a complete loss of resilience. The observation was immediately confirmed by the independent analysis of correlation properties of intraday physical activity levels fluctuations collected by wearable devices. We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.
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