Evidence map›Paper›PMID 34035177›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting

Yvonne Azasi, Leanne M Low, Ashley N Just, Sai S R Raghavan, Christian W Wang, Paola Valenzuela-Leon, J Alexandra Rowe, Joseph D Smith, Thomas Lavstsen, Louise Turner and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Yvonne AzasiLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852.
Leanne M LowLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852.ORCID 0000-0002-1976-3767
Ashley N JustCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-7993-9867
Sai S R RaghavanCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-2575-2685
Christian W WangCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0003-3140-6989
Paola Valenzuela-LeonLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852.ORCID 0000-0002-5740-5178
J Alexandra RoweCentre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, United Kingdom.ORCID 0000-0002-7702-1892
Joseph D SmithCenter for Global Infectious Disease Resesarch, Seattle Children's Research Institute, Seattle, WA 98109.ORCID 0000-0002-7915-6360
Thomas LavstsenCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark lturner@sund.ku.dk thomasl@sund.ku.dk ecalvo@niaid.nih.gov lmiller@niaid.nih.gov.ORCID 0000-0002-3044-4249
Louise TurnerCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark lturner@sund.ku.dk thomasl@sund.ku.dk ecalvo@niaid.nih.gov lmiller@niaid.nih.gov.ORCID 0000-0003-4494-2289
Eric CalvoLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852; lturner@sund.ku.dk thomasl@sund.ku.dk ecalvo@niaid.nih.gov lmiller@niaid.nih.gov.ORCID 0000-0001-7880-2730
Louis H MillerLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852; lturner@sund.ku.dk thomasl@sund.ku.dk ecalvo@niaid.nih.gov lmiller@niaid.nih.gov.
National Institute of Allergy and Infectious Diseases · USUniversity of Copenhagen · DKCentre for Immunity, Infection and Evolution · GBInfectious Disease Research Institute · US

Funding

Malaria Parasite Receptors And Host Cell LigandsZIAAI000241 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MILLER, LOUIS · 2009 to 2025
$15.3M
Arthropod saliva in vector-borne disease transmission: Functional analysis of novel domains in salivary secretionsZIAAI001246 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CALVO, ERIC · 2019 to 2025
$10.0M
Molecular Mechanisms in Pediatric Cerebral Malaria Pathogenesis and ImmunityR01AI141602 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI SEYDEL, KARL BOYNTON, SMITH, JOSEPH D · 2019 to 2022
$2.9M
NIAID NIH HHS R01 AI141602
6 · The paper itself

Abstract

Cytoadhesion of

Indexed as

Bacterial AdhesionAmino Acid SequenceCell LineComplement C1Conserved SequenceHumansPlasmodium falciparumProtozoan ProteinsComplement C1erythrocyte membrane protein 1, Plasmodium falciparumProtozoan ProteinsC1scytoadhesionEPCRmalariaPfEMP1

Identifiers

PMID34035177
PMCPMC8179237
OpenAlexW3165605343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.