ArticleProceedings of the National Academy of Sciences of the United States of America2021
Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived
Open access · greenAbstract readValidation Study
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Neural excitation/inhibition imbalance and neurodevelopmental pathology in human copy number variant syndromes: a systematic review.Journal of neurodevelopmental disorders · 2025Pooled it
- Neurexin dysfunction in neurodevelopmental and neuropsychiatric disorders: a PRIMSA-based systematic review through iPSC and animal models.Frontiers in behavioral neuroscience · 2024Pooled it
- Association of Plasma Neurexin-3 with Severity of Schizophrenia.Annals of neurosciences · 2026Article
- Developmentally dynamic, non-convergent transcriptomic profiles in CNV models for schizophrenia risk.Molecular psychiatry · 2026Article
- Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.Nature neuroscience · 2026Article
- Self-organized anteroposterior regionalization of early midbrain and hindbrain/spinal cords using micropatterned human pluripotent stem cells.SLAS technology · 2026Article
- A co-culture model of dopaminergic and glutamatergic neurons derived from patients with idiopathic schizophrenia reveals a hypodopaminergic phenotype.Molecular psychiatry · 2026Article
- Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons.Cell reports · 2026Article
- How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle.Psychiatry and clinical neurosciences · 2026Review
- Allele-specific rescue of neurexin behavioral phenotypes by monoamine-targeting compounds.bioRxiv : the preprint server for biology · 2026Article
- Functional implications of polygenic risk for schizophrenia in human neurons.Nature communications · 2026Article
- Roles of NRXN1 in neuropsychiatric disorders: from genetic lesion to molecular mechanism.Frontiers in neuroscience · 2026Review
- BAI adhesion-GPCRs perform distinct functions in neural development differentially controlled by RTN4R and C1ql ligands.Nature communications · 2025Article
- Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs.European journal of human genetics : EJHG · 2025Article
- Patient-Derived Variants Define Constraints for Ligand Binding at the PDZ Domain of CASK.Journal of neurochemistry · 2025Article
- Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds.bioRxiv : the preprint server for biology · 2025Article
- Evidence of neurocognitive and resting state functional connectivity differences in carriers of NRXN1 deletions.Journal of neurodevelopmental disorders · 2025Article
- Targeted splicing approach for alleviation of a neurexin 1 haploinsufficiency model.Molecular psychiatry · 2025Article
- Distinct Synaptic Mechanisms DrivebioRxiv : the preprint server for biology · 2025Article
- Dynamic convergence of neurodevelopmental disorder risk genes across neurodevelopment.bioRxiv : the preprint server for biology · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 6 institutions in 2 countries.
ChangHui PakDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305; cpak@umass.edu tcs1@stanford.edu.ORCID 0000-0003-4192-7665
Tamas DankoDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-2292-1508
Vincent R MirabellaChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901.
Jinzhao WangDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-7260-0676
Yingfei LiuInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-2303-576X
Madhuri VangipuramInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-7271-2689
Sarah GriederInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-5317-8553
Xianglong ZhangDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Thomas WardDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Yu-Wen Alvin HuangDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-4082-8008
Kang JinDepartment of Biomedical Informatics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0001-5638-040X
Philip DexheimerDepartment of Biomedical Informatics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0003-3965-6894
Eric BardesDepartment of Biomedical Informatics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Alexis MitelpunktDepartment of Biomedical Informatics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0002-4025-5302
Junyi MaFujifilm Cellular Dynamics, Inc., Madison, WI 53711.ORCID 0000-0002-9369-1271
Michael McLachlanFujifilm Cellular Dynamics, Inc., Madison, WI 53711.
Jennifer C MooreRutgers University Cell and DNA Repository Infinite Biologics, National Institute of Mental Health Repository and Genomics Resource, Rutgers University, Piscataway, NJ 08854.
Pingping QuDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Carolin PurmannDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-7691-1615
Jeffrey L DageEli Lilly and Company, Indianapolis, IN 46285.ORCID 0000-0002-2192-1699
Bradley J SwansonFujifilm Cellular Dynamics, Inc., Madison, WI 53711.
Alexander E UrbanDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Bruce J AronowDepartment of Biomedical Informatics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Zhiping P PangChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901.
Douglas F LevinsonDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Marius WernigInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.
Thomas C SüdhofDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305; cpak@umass.edu tcs1@stanford.edu.
Stanford University · USCincinnati Children's Hospital Medical Center · USFujifilm (United States) · USHoward Hughes Medical Institute · USRutgers, The State University of New Jersey · USEli Lilly (United States) · US
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MSpecial EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2MMultimodal analysis of high-risk psychosis mutations in induced neuronal cellsU19MH104172 · NIMH · STANFORD UNIVERSITY · PI LEVINSON, DOUGLAS FREDERICK · 2014 to 2018
$9.7MMOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059571 · NIMH · UNIVERSITY OF CHICAGO · PI GEJMAN, PABLO V. · 1999 to 2007
$8.0MFunction of NeurexinsR01MH052804 · NIMH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI SUDHOF, THOMAS C. · 1994 to 2024
$3.7MMOLECULAR GENETICS OF SCHIZOPHRENIAR01MH060879 · NIMH · WASHINGTON UNIVERSITY · PI CLONINGER, C. ROBERT · 1999 to 2006
$2.7MMolecular dissection of synaptic dysfunction in mental disordersR01MH122519 · NIMH · UNIVERSITY OF MASSACHUSETTS AMHERST · PI PAK, CHANGHUI · 2020 to 2024
$2.3MMOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059586 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SILVERMAN, JEREMY M. · 1999 to 2006
$1.9MMOLECULAR GENETICS OF SCHIZOPHRENIAR01MH061675 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI LEVINSON, DOUGLAS FREDERICK · 1999 to 2007
$1.8MMOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059587 · NIMH · EMORY UNIVERSITY · PI AMIN, FAROOQ · 1999 to 2006
$1.8MMOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059565 · NIMH · UNIVERSITY OF COLORADO DENVER · PI FREEDMAN, ROBERT · 1999 to 2006
$1.7MMOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059588 · NIMH · UNIVERSITY OF QUEENSLAND · PI MOWRY, BRYAN JOHN · 1999 to 2006
$1.4MNHGRI NIH HHS P50 HG007735NIA NIH HHS R00 AG054616NICHD NIH HHS F32 HD078051NIMH NIH HHS F30 MH108321NIMH NIH HHS R01 MH052804NIMH NIH HHS R01 MH059565NIMH NIH HHS R01 MH059566NIMH NIH HHS R01 MH059571NIMH NIH HHS R01 MH059586NIMH NIH HHS R01 MH059587NIMH NIH HHS R01 MH059588NIMH NIH HHS R01 MH060870NIMH NIH HHS R01 MH060879NIMH NIH HHS R01 MH061675NIMH NIH HHS R01 MH067257NIMH NIH HHS R01 MH122519NIMH NIH HHS U19 MH104172NIMH NIH HHS U24 MH068457
Abstract
Heterozygous
Indexed as
MutationCalcium-Binding ProteinsCase-Control StudiesCells, CulturedCell TransdifferentiationCohort StudiesEmbryonic Stem CellsGene ExpressionGuanylate KinasesHeterozygoteHumansInduced Pluripotent Stem CellsNeural Cell Adhesion MoleculesNeuronsNeurotransmitter AgentsSchizophreniaCalcium-Binding ProteinsCASK kinasesGuanylate KinasesNeural Cell Adhesion MoleculesNeurotransmitter AgentsNRXN1 protein, humanneurexinNMDA receptorschizophreniasynapse formationsynaptic transmission
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.