ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Increased Visual Sensitivity and Occipital Activity in Patients With Hemianopia Following Vision Rehabilitation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Interventions for Visual Field Loss After Acquired Brain Injury: A Systematic Review.Life (Basel, Switzerland) · 2026Review
- Generalisation of training-induced recovery in occipital stroke: neurochemical and fMRI correlates.bioRxiv : the preprint server for biology · 2026Article
- Dynamic neural compensation for distorted orientation perception in chronic astigmatism.iScience · 2025Article
- What V1 Damage Can Teach Us About Visual Perception and Learning.Annual review of vision science · 2025Review
- Supervised and unsupervised rehabilitation of visual field defect: cohort investigation of eye movement training at a clinical setting and at home.Experimental brain research · 2025Article
- Voxel-Based Lesion-Symptom Mapping Localizes Residual Visual Function in Hemianopia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Rehabilitating homonymous visual field deficits: white matter markers of recovery-stage 2 registered report.Brain communications · 2024Article
- Ameliorating Hemianopia with Multisensory Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Placebo effect after visual restitution training: no eye-tracking controlled perimetric improvement after visual border stimulation in late subacute and chronic visual field defects after stroke.Frontiers in neurology · 2023Article
- A deep neural network model of the primate superior colliculus for emotion recognition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Enhancement of visual perception by combining transcranial electrical stimulation and visual perceptual training.Medical review (2021) · 2022Review
- Neural Mechanisms of Visual Field Recovery after Perceptual Training in Cortical Blindness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Spared perilesional V1 activity underlies training-induced recovery of luminance detection sensitivity in cortically-blind patients.Nature communications · 2021Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Hemianopia, loss of vision in half of the visual field, results from damage to the visual pathway posterior to the optic chiasm. Despite negative effects on quality of life, few rehabilitation options are currently available. Recently, several long-term training programs have been developed that show visual improvement within the blind field, although little is known of the underlying neural changes. Here, we have investigated functional and structural changes in the brain associated with visual rehabilitation. Seven human participants with occipital lobe damage enrolled in a visual training program to distinguish which of two intervals contained a drifting Gabor patch presented within the blind field. Participants performed ∼25 min of training each day for 3-6 months and undertook psychophysical tests and a magnetic resonance imaging scan before and after training. A control group undertook psychophysical tests before and after an equivalent period without training. Participants who were not at ceiling on baseline tests showed on average 9.6% improvement in Gabor detection, 8.3% in detection of moving dots, and 9.9% improvement in direction discrimination after training. Importantly, psychophysical improvement only correlated with improvement in Humphrey perimetry in the trained region of the visual field. Whole-brain analysis showed an increased neural response to moving stimuli in the blind visual field in motion area V5/hMT. Using a region-of-interest approach, training had a significant effect on the blood oxygenation level-dependent signal compared with baseline. Moreover, baseline V5/hMT activity was correlated to the amount of improvement in visual sensitivity using psychophysical and perimetry tests. This study, identifying a critical role for V5/hMT in boosting visual function, may allow us to determine which patients may benefit most from training and design adjunct interventions to increase training effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.