ArticleJournal of neurology, neurosurgery, and psychiatry2021
Subjective cognitive complaints at age 70: associations with amyloid and mental health.
Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Depression and anxiety modify cognitive concerns associated with amyloid and early clinical impairment.Neuropsychology · 2026Article
- The predictive role of olfactory identification on episodic memory and mild cognitive impairment: Results from the CIMA-Q cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort.BMC research notes · 2026Article
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- Supraspan memory performance is impaired in subjective cognitive impairment compared to cognitively unimpaired individuals.Scientific reports · 2025Article
- Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults.Brain : a journal of neurology · 2025Article
- The mobile everyday cognition scale (mECog): Development and pilot testing.The Clinical neuropsychologist · 2025Article
- Subjective Memory Complaints: A Conceptual Analysis.Journal of multidisciplinary healthcare · 2025Review
- Subjective cognitive decline-a neglected but preventable public health concern: development and validation of a risk prediction model for subjective cognitive decline in older adults: a cross-sectional survey study from Anhui Province in eastern China.Frontiers in public health · 2025Article
- Cerebral Amyloidosis in Individuals with Subjective Cognitive Decline: From Genetic Predisposition to Actual Cerebrospinal Fluid Measurements.Biomedicines · 2024Article
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- Updating the study protocol: Insight 46 - a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development - phases 2 and 3.BMC neurology · 2024Article
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- The relationship between learning slopes and Alzheimer's Disease biomarkers in cognitively unimpaired participants with and without subjective memory concerns.Journal of clinical and experimental neuropsychology · 2023Article
- How Does Exposure to Dementia Relate to Subjective Cognition? A Systematic Review.Innovation in aging · 2023Review
- Lower visual processing speed relates to greater subjective cognitive complaints in community-dwelling healthy older adults.Frontiers in psychiatry · 2023Article
- Subjective cognitive complaints are important in PD-MCI criteria: Associations with CSF markers and cognitive decline.Parkinsonism & related disorders · 2023Article
- Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid?Alzheimer's research & therapy · 2022Article
- Article
- Alzheimer's disease neuropathology and longitudinal change in subjective cognitive complaints.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate subjective cognitive decline (SCD) in relation to β-amyloid pathology and to test for associations with anxiety, depression, objective cognition and family history of dementia in the Insight 46 study.
methodsCognitively unimpaired ~70-year-old participants, all born in the same week in 1946 (n=460, 49% female, 18% amyloid-positive), underwent assessments including the SCD-Questionnaire (MyCog). MyCog scores were evaluated with respect to
resultsAnxiety (mean (SD) trait anxiety score: 4.4 (3.9)) was associated with higher MyCog scores, especially in women. MyCog scores were higher in amyloid-positive compared with amyloid-negative individuals (adjusted means (95% CIs): 5.3 (4.4 to 6.1) vs 4.3 (3.9 to 4.7), p=0.044), after accounting for differences in anxiety. PACC (mean (SD) -0.05 (0.68)) and family history of dementia (prevalence: 23.9%) were not independently associated with MyCog scores. The informant's perception of SCD was generally in accordance with that of the participant.
conclusionsThis cross-sectional study demonstrates that symptoms of SCD are associated with both β-amyloid pathology, and more consistently, trait anxiety in a population-based cohort of older adults, at an age when those who are destined to develop dementia are still likely to be some years away from symptoms. This highlights the necessity of considering anxiety symptoms when assessing Alzheimer's disease pathology and SCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.