ArticleScience immunology2021
Polyclonal expansion of TCR Vbeta 21.3
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Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.
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102citing papers in PubMed, 1 pooled it
26.3field-weighted citation impact, top 1% of its field
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Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- The protective effect of COVID-19 vaccines on developing multisystem inflammatory syndrome in children (MIS-C): a systematic literature review and meta-analysis.Pediatric rheumatology online journal · 2023Pooled it
- High-dose intravenous immunoglobulin versus albumin 4% in paediatric toxic shock syndrome: a randomised controlled feasibility study.Archives of disease in childhood · 2024Trial
- Characterization of SARS-CoV-2 and common cold coronavirus-specific T-cell responses in MIS-C and Kawasaki disease children.European journal of immunology · 2022Trial
- SARS-CoV-2 Reinfection and Risk of Multisystem Inflammatory Syndrome in Children: A Case-control Study.The Pediatric infectious disease journal · 2026Article
- Shared TCR Vβ21.3+ T cell immunological signature between MIS-A and MIS-C.Journal of human immunity · 2026Article
- Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Potential Mechanisms and Hypotheses for Pathogenic Microorganisms Triggering Kawasaki Disease.Clinical reviews in allergy & immunology · 2025Review
- The seven enigmas of SARS-CoV-2: from the past to the future.Journal of human immunity · 2025Article
- Polyclonal Vβ21.3 expansion in multisystem inflammatory syndrome in children despite SARS-CoV-2 vaccination.RMD open · 2025Article
- The Etiopathogenesis of Kawasaki Disease: Evolving Understanding of Diverse Triggers.Immunity, inflammation and disease · 2025Review
- Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases.Disease models & mechanisms · 2025Article
- Article
- Article
- Observational
- Human genetic and immunological determinants of SARS-CoV-2 infection and multisystem inflammatory syndrome in children.Clinical and experimental immunology · 2025Review
- Distinctive T-cell receptor repertoire in paediatric inflammatory multisystem syndrome temporally associated with coronavirus disease 2019/multisystem inflammatory syndrome in children patients: possible thymus involvement.Clinical and experimental immunology · 2025Article
- Case Report: Two episodes of hyperinflammation in an infant consistent with multisystem inflammatory syndrome in children: recurrence or rather two different diseases?Frontiers in pediatrics · 2025Article
- Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C).The Journal of experimental medicine · 2024Article
- Nationwide Survey of Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019 in Japan.Journal of clinical immunology · 2024Article
- Prognostic Value of Baseline Serum Pro-Inflammatory Cytokines in Severe Multisystem Inflammatory Syndrome in Children.Journal of clinical medicine · 2024Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
50 authors at 12 institutions in 2 countries.
Marion MoreewsCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0002-5116-2443
Kenz Le Gouge *Sorbonne Université, UPMC Univ Paris 06, INSERM UMRS 959, Immunology Immunopathology-Immunotherapy (i3), Paris, France.ORCID 0000-0003-4402-199X
Samira Khaldi-Plassart *(RAISE), France; Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon.
Rémi Pescarmona *CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0002-7218-3294
Anne-Laure MathieuCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France. alexandre.belot@chu-lyon.fr.
Christophe MalcusHospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France.ORCID 0000-0002-1820-7996
Sophia DjebaliCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0002-0567-5387
Alicia BellomoCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0003-3816-4257
Olivier DauwalderCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0003-1722-1582
Magali PerretCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0002-9215-5186
Marine VillardCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0002-3905-8993
Emilie ChopinCellular Biotechnology Department and Biobank, Hospices Civils de Lyon, Lyon, France.
Isabelle RouvetCellular Biotechnology Department and Biobank, Hospices Civils de Lyon, Lyon, France.
Francois VandeneshCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0001-9412-7106
Céline DupieuxCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0001-7388-4087
Robin PouyauRéanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France.ORCID 0000-0001-7021-0140
Sonia TeyssedreRéanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France.
Margaux GuerderRéanimation Pédiatrique Hôpital Femme-Mère-Enfant Hospices Civils de Lyon, Bron, France.
Tiphaine LouazonService de pédiatrie, Centre Hospitalier de Valence, France.ORCID 0000-0003-4851-9023
Anne Moulin-ZinschUnité medico-chirurgicale des cardiopathies congénitales, hôpital Louis-Pradel, hospices civils de Lyon, 69677 Bron, France.
Marie DuperrilPediatric intensive care unit - University hospital of Saint-Étienne, France.ORCID 0000-0002-7258-4063
Hugues PaturalPediatric intensive care unit - University hospital of Saint-Étienne, France.
Lisa Giovannini-ChamiPediatric Pulmonology and Allergology Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.
Aurélie PortefaixCenter of Clinical Investigation, Lyon University Hospital, Bron, France.
Behrouz KassaiCenter of Clinical Investigation, Lyon University Hospital, Bron, France.
Fabienne VenetCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0003-0462-4235
Guillaume MonneretHospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437 Lyon, France.ORCID 0000-0002-9961-5739
Christine LombardImmunology Laboratory, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite.ORCID 0000-0002-4204-9510
Hugues FlodropsService de Pédiatrie, Groupe Hospitalier Sud Réunion, CHU de La Réunion, Saint Pierre, La Réunion, France.ORCID 0000-0001-5483-6987
Jean-Marie De GuillebonService de Néphrologie, Rhumatologie pédiatrique, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.
Fanny BajolleHôpital Necker Enfants Malades, Centre de référence M3C, AP-HP, Paris, France.ORCID 0000-0002-1106-0987
Valérie LaunayUrgences pédiatriques, Hôpital femme Mère Enfant, Hospices Civils de Lyon, Bron, France.
Paul BastardLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-5926-8437
Shen-Ying ZhangLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Valérie DuboisEFS Auvergne Rhône Alpes, laboratoire Histocompatibilité, 111, rue Elisée-Reclus, 69150 Décines, France.ORCID 0000-0002-1169-7697
Olivier ThaunatCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0002-3648-8963
Jean-Christophe RichardMédecine Intensive-Réanimation, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.ORCID 0000-0003-1503-3035
Mehdi MezidiMédecine Intensive-Réanimation, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
Omran AllatifCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0002-2539-972X
Kahina SakerCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.
Marlène DreuxCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0002-6607-4796
Laurent AbelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-7016-6493
Jean-Laurent CasanovaLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-7782-4169
Jacqueline MarvelCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0001-6241-459X
Sophie Trouillet-AssantCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.ORCID 0000-0001-6439-4705
David KlatzmannSorbonne Université, UPMC Univ Paris 06, INSERM UMRS 959, Immunology Immunopathology-Immunotherapy (i3), Paris, France.ORCID 0000-0002-0054-3422
Thierry Walzer *CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.
Encarnita Mariotti-Ferrandiz *Sorbonne Université, UPMC Univ Paris 06, INSERM UMRS 959, Immunology Immunopathology-Immunotherapy (i3), Paris, France.ORCID 0000-0002-8770-0186
Etienne Javouhey *EA 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, 69003, Lyon, France.
Alexandre BelotCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France. alexandre.belot@chu-lyon.fr.ORCID 0000-0003-4902-5332
Université Claude Bernard Lyon 1 · FRInserm · FRHôpital Femme Mère Enfant · FRHospices Civils de Lyon · FRUniversité de Lyon · FRCentre Hospitalier de Valence · FRCentre Hospitalier Universitaire de La Réunion · FRFondation Lenval · FRHôpital Necker-Enfants Malades · FRHoward Hughes Medical Institute · USInstitute Cancer De La Loire Lucien Neuwirth · FRUniversité Côte d'Azur · FR
Funding
Howard Hughes Medical Institute
Abstract
Multiple Inflammatory Syndrome in Children (MIS-C) is a delayed and severe complication of SARS-CoV-2 infection that strikes previously healthy children. As MIS-C combines clinical features of Kawasaki disease and Toxic Shock Syndrome (TSS), we aimed to compare the immunological profile of pediatric patients with these different conditions. We analyzed blood cytokine expression, and the T cell repertoire and phenotype in 36 MIS-C cases, which were compared to 16 KD, 58 TSS, and 42 COVID-19 cases. We observed an increase of serum inflammatory cytokines (IL-6, IL-10, IL-18, TNF-α, IFNγ, CD25s, MCP1, IL-1RA) in MIS-C, TSS and KD, contrasting with low expression of HLA-DR in monocytes. We detected a specific expansion of activated T cells expressing the Vβ21.3 T cell receptor β chain variable region in both CD4 and CD8 subsets in 75% of MIS-C patients and not in any patient with TSS, KD, or acute COVID-19; this correlated with the cytokine storm detected. The T cell repertoire returned to baseline within weeks after MIS-C resolution. Vβ21.3+ T cells from MIS-C patients expressed high levels of HLA-DR, CD38 and CX3CR1 but had weak responses to SARS-CoV-2 peptides in vitro
Indexed as
AdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChildChild, PreschoolCOVID-19CytokinesHLA-DR AntigensHumansLymphocyte ActivationReceptors, Antigen, T-Cell, alpha-betaSARS-CoV-2Systemic Inflammatory Response SyndromeCytokinesHLA-DR AntigensReceptors, Antigen, T-Cell, alpha-beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.