Evidence map›Paper›PMID 34035083›Full record

ArticleCancer research2021

LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That Support

Samuel A Miller, Robert A Policastro, Shruthi Sriramkumar, Tim Lai, Thomas D Huntington, Christopher A Ladaika, Daeho Kim, Chunhai Hao, Gabriel E Zentner, Heather M O'Hagan

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 175 citations in OpenAlex.

  1. CD27 Agonist Antibodies Mediate Clinical Responses through Intratumoral Stimulation in B-cell Malignancies: Multicenter RiVa Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
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  11. Development of a prognostic prediction model incorporatingJournal of gastrointestinal oncology · 2026
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  15. Diverse infection models demonstrate robust resistance ofbioRxiv : the preprint server for biology · 2026
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Samuel A Miller *Genome, Cell, and Developmental Biology, Department of Biology, Indiana University Bloomington, Bloomington, Indiana.
Robert A Policastro *Genome, Cell, and Developmental Biology, Department of Biology, Indiana University Bloomington, Bloomington, Indiana.
Shruthi SriramkumarMedical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana.ORCID 0000-0003-1308-2546
Tim LaiMedical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana.ORCID 0000-0002-6746-1595
Thomas D HuntingtonMedical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana.
Christopher A LadaikaGenome, Cell, and Developmental Biology, Department of Biology, Indiana University Bloomington, Bloomington, Indiana.
Daeho KimDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0002-6582-0806
Chunhai HaoDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Gabriel E ZentnerGenome, Cell, and Developmental Biology, Department of Biology, Indiana University Bloomington, Bloomington, Indiana.ORCID 0000-0002-0801-7646
Heather M O'HaganMedical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana. hmohagan@indiana.edu.ORCID 0000-0001-9750-5088
Indiana University Bloomington · USIndiana University Health · USIndiana University – Purdue University Indianapolis · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Indiana Clinical and Translational Sciences InstituteTL1TR001107 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$2.0M
NCATS NIH HHS TL1 TR001107NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA082709
6 · The paper itself

Abstract

Despite the connection of secretory cells, including goblet and enteroendocrine (EEC) cells, to distinct mucus-containing colorectal cancer histologic subtypes, their role in colorectal cancer progression has been underexplored. Here, our analysis of The Cancer Genome Atlas (TCGA) and single-cell RNA-sequencing data demonstrates that EEC progenitor cells are enriched in

Indexed as

DNA MethylationAnimalsColorectal NeoplasmsDisease Models, AnimalEnteroendocrine CellsHeterograftsHistone DemethylasesHT29 CellsHumansMiceProto-Oncogene Proteins B-rafStem CellsBRAF protein, humanHistone DemethylasesKDM1A protein, humanProto-Oncogene Proteins B-raf

Identifiers

PMID34035083
PMCPMC8513805
OpenAlexW3164659906

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.