Evidence map›Paper›PMID 34035002›Full record

GuidelineAnnals of the rheumatic diseases2021

EULAR recommendations for intra-articular therapies.

Jacqueline Uson, Sebastián Cruz Rodriguez-García, Raul Castellanos-Moreira, Terence W O'Neill, Michael Doherty, Mikael Boesen, Hemant Pandit, Ingrid Möller Parera, Valentina Vardanyan, Lene Terslev and 8 more

2 registry-linked trialsOpen access · bronzeAbstract readPractice Guideline
In one paragraph

Guideline in Annals of the rheumatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05139875 phase4completednot on this mapstarted 2022, after this paper: background citation

A Comparative Study of Betamethasone (Diprospan) and Triamcinolone Acetonide as Single Intra-Articular Injection in Knee Osteoarthritis, A Double-Blinded, Randomized Controlled Trial

TypeinterventionalSponsorThammasat UniversityRan2022 to 2024Enrolled105ConditionsKnee OsteoarthritisArmsBetamethasone Dipropionate / Betamethasone Sodium Phosphate, Triamcinolone Acetonide 40mg/mL
NCT06768294 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Baricitinib in Calcium PyrophosphAte DePosiTion DIseaSe Trial - a Proof of Concept Phase II Clinical Trial

TypeinterventionalSponsorI.R.C.C.S Ospedale Galeazzi-Sant'AmbrogioRan2025 to 2027Enrolled32ConditionsCalcium Pyrophosphate Deposition Disease, ChondrocalcinosisArmsBaricitinib 4 MG Oral Tablet, Methylprednisolone (Corticosteroid), Colchicine 1 MG Oral Tablet, Hydroxychloroquine 200 mg, Methotrexate + Folic Acid
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Article
  9. Review
  10. Intra-articular glucocorticoid injections for knee osteoarthritis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 16 institutions in 8 countries.

Jacqueline UsonRheumatology Deptarment, Hospital Universitario Móstoles, Universidad Rey Juan Carlos, Madrid, Spain jusonjaeger@gmail.com.ORCID 0000-0002-2933-4878
Sebastián Cruz Rodriguez-GarcíaRheumatology Department, Hospital Universitario de la Princesa, Madrid, Spain.ORCID 0000-0002-7773-151X
Raul Castellanos-MoreiraRheumatology Department, Centre Sociosanitari Hospital Clínic i Provincial de Barcelona, Barcelona, Spain.ORCID 0000-0002-4104-4101
Terence W O'NeillArthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, UK.
Michael DohertyAcaedemic Rheumatology, University of Nottingham, Nottingham, UK.
Mikael BoesenMusculoskeletal research Unit, Department of Radiology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Hemant PanditOrthopaedic Surgery, Chapel Allerton Hospital, University of Leeds, Leeds, UK.
Ingrid Möller PareraReumatology Deptarment, Instituto Poal, Barcelona, Spain.
Valentina VardanyanRheumatology Department, Yerevan State Medical University Named after Mkhitar Heratsi, Yerevan, Armenia.
Lene TerslevCenter for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.
Willm Uwe KampenNuclear Medicine Spitalerhof, Radiologische Allianz, Hamburg, Germany.
Maria-Antonietta D'AgostinoRheumatology Department, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy.
Francis BerenbaumRheumatology Department, Sorbonne Université, Paris, France.ORCID 0000-0001-8252-7815
Elena NikiphorouRheumatology Research, Acaedemic Department of Rheumatology, King's College London, London, UK.ORCID 0000-0001-6847-3726
Irene A PitsillidouEULAR Patient Research Partner, Cyprus League Against Rheumatism, Nicosia, Cyprus.
Jenny de la Torre-AbokiRheumatology Day Hospital, Hospital General Universitario de Alicante, Alicante, Spain.ORCID 0000-0002-4905-2034
Loreto CarmonaInstituto de Salud Musculoesquelética (INMUSC), Madrid, Spain.ORCID 0000-0002-4401-2551
Esperanza NaredoRheumatology Department and Joint and Bone Research Unit, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
Center for Rheumatology · USEuropean League Against Rheumatism · CHFrederiksberg Hospital · DKHospital Clínic de Barcelona · ESHospital General Universitario de Alicante Doctor Balmis · ESHospital Universitario de La Princesa · ESInstituto de Salud Musculoesquelética · ESKing's College London · GBRigshospitalet · DKSorbonne Université · FRUnited States Bone and Joint Initiative · USUniversidad Rey Juan Carlos · ESUniversità Cattolica del Sacro Cuore · ITUniversity of Leeds · GBUniversity of Manchester · GBUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo establish evidence-based recommendations to guide health professionals using intra-articular therapies (IAT) in adult patients with peripheral arthropathies.

methodsA multidisciplinary international task force established the objectives, users and scope and the need for background information, including systematic literature reviews) and two surveys addressed to healthcare providers and patients throughout Europe. The evidence was discussed in a face-to-face meeting, recommendations were formulated and subsequently voted for anonymously in a three-round Delphi process to obtain the final agreement. The level of evidence was assigned to each recommendation with the Oxford levels of evidence.

resultsRecommendations focus on practical aspects to guide health professionals before, during and after IAT in adult patients with peripheral arthropathies. Five overarching principles and 11 recommendations were established, addressing issues related to patient information, procedure and setting, accuracy, routine and special aseptic care, safety issues and precautions to be addressed in special populations, efficacy and safety of repeated joint injections, use of local anaesthetics and aftercare.

conclusionWe have developed the first evidence and expert opinion-based recommendations to guide health professionals using IAT. We hope that these recommendations will be included in different educational programmes, used by patient associations and put into practice via scientific societies to help improve uniformity and quality of care when performing IAT in peripheral adult joints.

Indexed as

Antirheumatic AgentsDrainageEuropeGlucocorticoidsGoutHand JointsHumansHyaluronic AcidInjections, Intra-ArticularJoint DiseasesOsteoarthritisOsteoarthritis, KneeRheumatologySocieties, MedicalViscosupplementsAntirheumatic AgentsGlucocorticoidsHyaluronic AcidViscosupplementsarthritishealth careosteoarthritisoutcome and process assessment

Identifiers

PMID34035002
PMCPMC8458067
OpenAlexW3165310083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.