Evidence map›Paper›PMID 34034934›Full record

ArticleJournal of cardiothoracic and vascular anesthesia2021

The Use of Factor Eight Inhibitor Bypass Activity (FEIBA) for the Treatment of Perioperative Hemorrhage in Left Ventricular Assist Device Implantation.

Christian O'Donnell, Alexander J Rodriguez, Jai Madhok, Husham Sharifi, Hanjay Wang, Connor G O'Brien, Jack Boyd, William Hiesinger, Joe Hsu, Charles C Hill

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic and vascular anesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Coagulation and Transfusion Updates From 2021.Journal of cardiothoracic and vascular anesthesia · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Christian O'DonnellDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA.
Alexander J RodriguezDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA.
Jai MadhokDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA.
Husham SharifiDepartment of Medicine (Pulmonary, Allergy & Critical Care Medicine), Stanford University School of Medicine, Stanford, CA.
Hanjay WangDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA.
Connor G O'BrienDepartment of Cardiovascular Medicine, University of California, San Francisco, CA.
Jack BoydDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA.
William HiesingerDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA.
Joe HsuDepartment of Medicine (Pulmonary, Allergy & Critical Care Medicine), Stanford University School of Medicine, Stanford, CA.
Charles C HillDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA. Electronic address: chill1@stanford.edu.
Stanford University · USStanford Medicine · USUniversity of California, San Francisco · US

Funding

A critical role for macrophage ferroptosis in promoting fungal invasion in lung transplant recipientsR01HL157414 · NHLBI · STANFORD UNIVERSITY · PI HSU, JOE L · 2021 to 2025
$3.0M
NHLBI NIH HHS R01 HL157414
6 · The paper itself

Abstract

objectiveTo test the hypothesis that factor eight inhibitor bypassing activity (FEIBA) can be used to control bleeding following left ventricular assist device (LVAD) implantation without increasing the 14-day composite thrombotic outcome of pump thrombus, ischemic cerebrovascular accidents, pulmonary embolism, and deep venous thrombosis.

designRetrospective cohort study.

settingAcademic hospital.

participantsThree hundred nineteen consecutive patients who underwent LVAD implantation (December 1, 2009 to December 30, 2018).

interventionFEIBA administered to control perioperative hemorrhage. MEASUREMENTS AND MAIN

resultsThe 82 patients (25.7%) in the FEIBA cohort had more risk factors for perioperative hemorrhage, such as lower preoperative platelet count (169 ± 66 v 194 ± 68 × 10

conclusionsIn this retrospective cohort study, the use of FEIBA (∼1,000 units, ∼13 units/kg) to control perioperative hemorrhage following LVAD implantation was not associated with increases in mortality or composite thrombotic outcome.

Indexed as

Heart-Assist DevicesHeart FailureBlood Coagulation FactorsFactor VIIIHemorrhageHumansRetrospective StudiesTreatment Outcomeanti-inhibitor coagulant complexBlood Coagulation FactorsFactor VIIICVADVTfactor 8 inhibitor bypass activityFEIBAleft ventricular assist deviceLVADPEperioperative hemorrhageprocoagulantspump thrombusthrombosisthrombotic events

Identifiers

PMID34034934
PMCPMC8842836
OpenAlexW3159272028

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.