ArticlePlant science : an international journal of experimental plant biology2021
AaMYB15, an R2R3-MYB TF in Artemisia annua, acts as a negative regulator of artemisinin biosynthesis.
Article in Plant science : an international journal of experimental plant biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 51 citations in OpenAlex.
- MYB Transcription Factors Negatively RegulatePlants (Basel, Switzerland) · 2026Article
- Jasmonate-Activated AaWRKY9-AabHLH93/AabHLH93-AaMYB7 Complexes Balance Artemisinin Biosynthesis in Artemisia annua.Plant biotechnology journal · 2026Article
- Cytochrome P450 gene family: cross-pathway functional conservation, novel catalytic reactions, and synthetic biology-driven applications in plant secondary metabolism.Frontiers in plant science · 2026Review
- Identification of DNA Methyltransferase/Demethylase Genes and 5-Azacytidine's Impact on β-Elemene and Methylation inBiology · 2025Article
- Single-nucleus transcriptomics reveal the morphogenesis and artemisinin biosynthesis in Artemisia annua glandular trichomes.Nature communications · 2025Article
- Analysis of Non-Polar Low-Molecular Metabolites in Citron (International journal of molecular sciences · 2025Article
- AaMYB121, a Novel R2-MYB-like Transcription Factor, Regulates Artemisinin Biosynthesis inInternational journal of molecular sciences · 2025Article
- A transcription factor of SHI family AaSHI1 activates artemisinin biosynthesis genes in Artemisia annua.BMC genomics · 2024Article
- Genome-Wide Identification of the CYP716 Gene Family inPlants (Basel, Switzerland) · 2024Article
- The Key Role of Plant Hormone Signaling Transduction and Flavonoid Biosynthesis Pathways in the Response of Chinese Pine (International journal of molecular sciences · 2024Article
- Advanced metabolic engineering strategies for increasing artemisinin yield inHorticulture research · 2024Article
- Functions of Representative Terpenoids and Their Biosynthesis Mechanisms in Medicinal Plants.Biomolecules · 2023Review
- Multilayered regulation of secondary metabolism in medicinal plants.Molecular horticulture · 2023Review
- Overexpression ofForestry research · 2023Article
- Transcriptome-wide identification of WRKY transcription factors and their expression profiles in response to methyl jasmonate inPlant signaling & behavior · 2022Article
- From Plant to Yeast-Advances in Biosynthesis of Artemisinin.Molecules (Basel, Switzerland) · 2022Review
- TcMYB8, a R3-MYB Transcription Factor, Positively Regulates Pyrethrin Biosynthesis inInternational journal of molecular sciences · 2022Article
- Cloning, characterization and functional analysis ofFrontiers in plant science · 2022Article
- MADS-box geneFrontiers in plant science · 2022Article
- Effects of Light on Secondary Metabolite Biosynthesis in Medicinal Plants.Frontiers in plant science · 2021Review
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Authors and funding
12 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Artemisinin is a secondary metabolite extracted from Artemisia annua. As an effective antimalarial component certified by WHO, artemisinin has extensive economical values. Numerous studies about transcription factors positively regulating artemisinin biosynthesis have been published while negative regulators are rarely reported. In the present study, we identified AaMYB15 as the first R2R3-MYB that negatively regulates artemisinin biosynthesis in A. annua. Experimental evidences showed that AaMYB15 is a transcription factor within nucleus and predominantly expressed in glandular secretory trichomes (GSTs) in A. annua where artemisinin is synthesized and accumulated. The expression of AaMYB15 was induced by dark and JA treatment. Overexpression of AaMYB15 led to a significant decline in the expression levels of key enzyme genes ADS, CYP, DBR2, and ALDH1 and a significant decrease in the artemisinin contents of transgenic A. annua. AaMYB15 directly bound to the promoter of AaORA, a reported positive regulator of artemisinin biosynthesis in JA signaling pathway, to repress its transcriptional activity, thus downregulating the expression levels of downstream key enzyme genes and negatively regulating the artemisinin biosynthesis. Our study provides candidate gene for improvement of A. annua germplasm and new insights into the artemisinin biosynthesis regulation network mediated by light and JA.
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