Evidence map›Paper›PMID 34034855›Full record

ArticleComparative medicine2021

Comparison of Insulins Glargine and Degludec in Diabetic Rhesus Macaques (

Samantha C Puglisi, Alexis L Mackiewicz, Amir Ardeshir, Laura M Garzel, Kari L Christe

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comparative medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samantha C PuglisiDepartment of Primate Medicine, Davis, California;, Email: spuglisi@ucdavis.edu.
Alexis L MackiewiczDepartment of Primate Medicine, Davis, California.
Amir ArdeshirCalifornia National Primate Research Center, Davis, California.
Laura M GarzelDepartment of Primate Medicine, Davis, California.
Kari L ChristeDepartment of Primate Medicine, Davis, California.

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
NIH HHS P51 OD011107
6 · The paper itself

Abstract

Treating and monitoring type 2 diabetes mellitus (T2DM) in NHP can be challenging. Multiple insulin and hypoglycemic therapies and management tools exist, but few studies demonstrate their benefits in a NHP clinical setting. The insulins glargine and degludec are long-acting insulins; their duration of action in humans exceeds 24 and 42 h, respectively. In the first of this study's 2 components, we evaluated whether insulin degludec could be dosed daily at equivalent units to glargine to achieve comparable blood glucose (BG) reduction in diabetic rhesus macaques (

Indexed as

Diabetes Mellitus, Type 2HypoglycemiaAnimalsBlood GlucoseBlood Glucose Self-MonitoringHumansHypoglycemic AgentsInsulin GlargineInsulin, Long-ActingMacaca mulattaBlood GlucoseHypoglycemic Agentsinsulin degludecInsulin GlargineInsulin, Long-Acting

Identifiers

PMID34034855
PMCPMC8223866
OpenAlexW3164727084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.