ArticleLipids in health and disease2021
A correlation study of the relationships between nonalcoholic fatty liver disease and serum triglyceride concentration after an oral fat tolerance test.
Article in Lipids in health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
- Hepatic lipid accumulation induced by mono-(2-ethylhexyl) phthalate and potential ERBB2-associated inflammatory signaling in NAFLD.Frontiers in pharmacology · 2026Article
- Mediating effect analysis of postprandial triglyceride on Omega-3 and nonalcoholic fatty liver disease in individuals with normal fasting lipid levels.Frontiers in physiology · 2026Article
- Dynamic Alterations of BMP9 in NAFLD: A Novel Hepatokine Marker of Metabolic Dysfunction and Disease Severity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Article
- Correlation Between the Levels of Fasting and Postprandial ApoB48 with Metabolic Syndrome: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study.Frontiers in endocrinology · 2025Article
- From meal to malfunction: exploring molecular pathways, biomarkers and interventions in postprandial cardiometabolic health.Frontiers in cardiovascular medicine · 2025Review
- Review
- Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study.Lipids in health and disease · 2024Article
- SIRT3 rs11246020 Polymorphism Associated Postprandial Triglyceride Dysmetabolism.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Serum Gamma Glutamyltransferase: A Biomarker for Identifying Postprandial Hypertriglyceridemia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- A Gender-, Age-, and Weight Status-Specific Analysis of the High Prevalence of Hyperuricemia Among Chinese Children and Adolescents with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- A bibliometric analysis and visualization of literature on non-fasting lipid research from 2012 to 2022.Frontiers in endocrinology · 2023Article
- The association between serum uric acid and hypertriglyceridemia: evidence from the national health and nutrition examination survey (2007-2018).Frontiers in endocrinology · 2023Article
- Correlation Between the Levels of ANGPTL3, ANGPTL4, ANGPTL8 and Postprandial Triglyceride-Rich Lipoprotein (TRL).Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Serum Fibroblast Growth Factor 21 Level After an Oral Fat Tolerance Test is Related to Postprandial Free Fatty Acid Level.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Oral fat tolerance testing identifies abnormal pancreatic β-cell function and insulin resistance in individuals with normal glucose tolerance.Journal of diabetes investigation · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide. Triglyceride (TG) accumulation is central to NAFLD development. People now spend most of their day in the postprandial state, and the measurement of postprandial blood lipid concentration can make up for the lack of simple detection of fasting blood lipids. Postprandial triglyceride (PTG) is commonly used as a surrogate for postprandial blood lipid concentrations, and many studies have shown that PTG is a risk factor for NAFLD. The aim of the present study was to investigate the relationship between PTG concentration during oral fat tolerance testing (OFTT) and NAFLD.
methodsA total of 472 Chinese adults, aged 25 to 65 years, were enrolled in the study. All the participants underwent OFTT. The serum concentrations of TG and other lipids were measured, and their relationships with NAFLD were analyzed.
resultsOf the 472 participants, 155 were diagnosed with NAFLD. The fasting and postprandial TG concentrations of the participants with NAFLD were higher than those of healthy participants (P < 0.05). The TG concentrations of the healthy participants peaked 4 h postprandially, whereas those of the participants with NAFLD peaked 6 h postprandially and reached higher peak values. Postprandial TG concentration was significantly associated with a higher risk of NAFLD.
conclusionsHigh PTG is positively related to a higher risk of NAFLD, and the PTG concentrations of patients with NAFLD are higher than in healthy individuals, with a delayed peak. Therefore, 4-h PTG may represent a potential marker of NAFLD.
trial registrationChiCTR1800019514 .
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