ArticleMicrobial cell factories2021
Stepwise metabolic engineering of Candida tropicalis for efficient xylitol production from xylose mother liquor.
Article in Microbial cell factories, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 47 citations in OpenAlex.
- Valorization of xylose mother liquor into salidroside by engineeredSynthetic and systems biotechnology · 2026Article
- Xylitol: A Promising Sweetener Produced byIndian journal of microbiology · 2026Review
- Biological production and downstream separation of xylitol usingRSC advances · 2026Article
- Research progress in the biosynthesis of xylitol: feedstock evolution from xylose to glucose.Biotechnology letters · 2024Review
- XylR Overexpression in Escherichia coli Alleviated Transcriptional Repression by Arabinose and Enhanced Xylitol Bioproduction from Xylose Mother Liquor.Applied biochemistry and biotechnology · 2024Article
- Construction of a xylose metabolic pathway in Trichosporonoides oedocephalis ATCC 16958 for the production of erythritol and xylitol.Biotechnology letters · 2023Article
- Development of engineered Candida tropicalis strain for efficient corncob-based xylitol-ethanol biorefinery.Microbial cell factories · 2023Article
- Biological production of xylitol by using nonconventional microbial strains.World journal of microbiology & biotechnology · 2022Review
- Development of a gRNA Expression and Processing Platform for Efficient CRISPR-Cas9-Based Gene Editing and Gene Silencing in Candida tropicalis.Microbiology spectrum · 2022Article
- Xylitol production by Pseudomonas gessardii VXlt-16 from sugarcane bagasse hydrolysate and cost analysis.Bioprocess and biosystems engineering · 2022Article
- Engineering the oleaginous yeast Candida tropicalis for α-humulene overproduction.Biotechnology for biofuels and bioproducts · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCommercial xylose purification produces xylose mother liquor (XML) as a major byproduct, which has become an inexpensive and abundant carbon source. A portion of this XML has been used to produce low-value-added products such as caramel but the remainder often ends up as an organic pollutant. This has become an issue of industrial concern. In this study, a uracil-deficient Candida tropicalis strain was engineered to efficiently convert XML to the commercially useful product xylitol.
resultsThe xylitol dehydrogenase gene was deleted to block the conversion of xylitol to xylulose. Then, an NADPH regeneration system was added through heterologous expression of the Yarrowia lipolytica genes encoding 6-phosphate-gluconic acid dehydrogenase and 6-phosphate-glucose dehydrogenase. After process optimization, the engineered strain, C. tropicalis XZX-B4ZG, produced 97.10 g L
conclusionsIn conclusion, this study performed a combination of metabolic engineering and process optimizing in C. tropicalis to enhance xylitol production from XML. The use of C. tropicalis XZX-B4ZG, therefore, provided a convenient method to transform the industrial by-product XML into the useful material xylitol.
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