ArticleJournal of psychopharmacology (Oxford, England)2021
Altered cerebellar-cortical resting-state functional connectivity in cannabis users.
Article in Journal of psychopharmacology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Altered reward-related resting-state network properties in adolescent cannabis use and depression.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
- Altered Functional Connectivity Dynamics Serving Cognitive Flexibility in Regular Cannabis Users.Addiction biology · 2025Article
- Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study.BMJ mental health · 2024Observational
- The endocannabinoid system in bovine tissues: characterization of transcript abundance in the growing Holstein steer.BMC veterinary research · 2024Article
- Disrupted topological properties of the structural brain network in patients with cerebellar infarction on different sides are associated with cognitive impairment.Frontiers in neurology · 2022Article
- Evidence of familial confounding of the association between cannabis use and cerebellar-cortical functional connectivity using a twin study.NeuroImage. Clinical · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundCannabis use has been associated with abnormalities in cerebellar mediated motor and non-motor (i.e. cognition and personality) phenomena. Since the cerebellum is a region with high cannabinoid type 1 receptor density, these impairments may reflect alterations of signaling between the cerebellum and other brain regions.
aimsWe hypothesized that cerebellar-cortical resting-state functional connectivity (rsFC) would be altered in cannabis users, relative to their non-using peers. It was also hypothesized that differences in rsFC would be associated with cannabis use features, such as age of initiation and lifetime use.
methodsCerebellar-cortical and subcortical rsFCs were computed between 28 cerebellar lobules, defined by a spatially unbiased atlas template of the cerebellum, and individual voxels in the cerebral regions, in 41 regular cannabis users (20 female) and healthy non-using peers (
resultsCannabis users demonstrated hyperconnectivity between the anterior cerebellar regions (i.e. lobule I-IV) with the posterior cingulate cortex, and hypoconnectivity between the rest of the cerebellum (i.e. Crus I and II, lobule VIIb, VIIIa, VIIIb, IX, and X) and the cortex. No associations were observed between features of cannabis use and rsFC.
conclusionsCannabis use was associated with altered patterns of rsFC from the cerebellum to the cerebral cortex which may have a downstream impact on behavior and cognition.
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