Evidence map›Paper›PMID 34034105›Full record

ArticleJournal of chromatography. A2021

Characterization of drug binding with alpha

Sandya R Beeram, Chenhua Zhang, Kyungah Suh, William A Clarke, David S Hage

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chromatography. A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Analysis of the binding of warfarin to glyoxal- and methylglyoxal-modified human serum albumin by ultrafast affinity extraction.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2022
    Article
  7. Evaluation of microcolumn stability in ultrafast affinity extraction for binding and rate studies.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sandya R BeeramDepartment of Chemistry, University of Nebraska, Lincoln, NE 68588, USA.
Chenhua ZhangDepartment of Chemistry, University of Nebraska, Lincoln, NE 68588, USA.
Kyungah SuhDepartment of Chemistry, University of Nebraska, Lincoln, NE 68588, USA.
William A ClarkeDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
David S HageDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: dhage1@unl.edu.
University of Nebraska–Lincoln · USJohns Hopkins University · US

Funding

CHROMATOGRAPHIC AUTOMATION OF IMMUNOASSAYSR01GM044931 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI HAGE, DAVID S · 1998 to 2014
$2.7M
CHROMATOGRAPHIC STUDIES OF FUNCTIONAL PROTEOMICSR01DK069629 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI HAGE, DAVID S · 2006 to 2017
$1.8M
NIDDK NIH HHS R01 DK069629NIGMS NIH HHS R01 GM044931
6 · The paper itself

Abstract

Many drugs bind to serum transport proteins, which can affect both drug distribution and activity in the body. α

Indexed as

Blood ProteinsChromatography, AffinityGlycosylationHumansLupus Erythematosus, SystemicOrosomucoidPharmaceutical PreparationsProtein BindingBlood ProteinsOrosomucoidPharmaceutical PreparationsAlpha(1)-acid glycoproteinDrug-protein bindingHuman serum albuminSystemic lupus erythematosusUltrafast affinity extraction

Identifiers

PMID34034105
PMCPMC8186453
OpenAlexW3161334228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.