Evidence map›Paper›PMID 34033965›Full record

ArticleThe journal of pain2021

Are Cardiometabolic Markers of Allostatic Load Associated With Pronociceptive Processes in Native Americans?: A Structural Equation Modeling Analysis From the Oklahoma Study of Native American Pain Risk.

Jamie L Rhudy, Bethany L Kuhn, Mara J Demuth, Felicitas A Huber, Natalie Hellman, Tyler A Toledo, Edward W Lannon, Shreela Palit, Michael F Payne, Cassandra A Sturycz and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Jamie L RhudyDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma. Electronic address: jamie-rhudy@utulsa.edu.
Bethany L KuhnDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Mara J DemuthDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Felicitas A HuberDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Natalie HellmanDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Tyler A ToledoDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Edward W LannonDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Shreela PalitDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma; Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, Florida.
Michael F PayneDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, Division of Behavioral Medicine & Clinical Psychology, Cincinnati, Ohio.
Cassandra A SturyczDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Parker A KellDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Yvette M GuerecaDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Erin N StreetDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Joanna O ShadlowDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
University of Tulsa · USCincinnati Children's Hospital Medical Center · USOklahoma State University at Tulsa · USUniversity of Florida · US

Funding

Native American Pain Disparities: Exploring Nociceptive Processing DifferencesR01MD007807 · NIMHD · UNIVERSITY OF TULSA · PI RHUDY, JAMIE LYNN · 2013 to 2016
$1.2M
NIMHD NIH HHS R01 MD007807
6 · The paper itself

Abstract

Native Americans (NAs) experience higher rates of chronic pain than the general U.S. population, but the risk factors for this pain disparity are unknown. NAs also experience high rates of stressors and cardiovascular and metabolic health disparities (eg, diabetes, cardiovascular disease) consistent with allostatic load (stress-related wear-and-tear on homeostatic systems). Given that allostatic load is associated with chronic pain, then allostatic load may contribute to their pain disparity. Data from 302 healthy, pain-free men and women (153 NAs, 149 non-Hispanic Whites [NHW]) were analyzed using structural equation modeling to determine whether cardiometabolic allostatic load (body mass index, blood pressure, heart rate variability) mediated the relationship between NA ethnicity and experimental measures of pronociceptive processes: temporal summation of pain (TS-pain) and the nociceptive flexion reflex (TS-NFR), conditioned pain modulation of pain (CPM-pain) and NFR (CPM-NFR), and pain tolerance. Results indicated that NAs experienced greater cardiometabolic allostatic load that was related to enhanced TS-NFR and impaired CPM-NFR. Cardiometabolic allostatic load was unrelated to measures of pain perception (CPM-pain, TS-pain, pain sensitivity). This suggests cardiometabolic allostatic load may promote spinal sensitization in healthy NAs, that is not concomitant with pain sensitization, perhaps representing a unique pain risk phenotype in NAs. PERSPECTIVE: Healthy, pain-free Native Americans experienced greater cardiometabolic allostatic load that was associated with a pronociceptive pain phenotype indicative of latent spinal sensitization (ie, spinal sensitization not associated with hyperalgesia). This latent spinal sensitization could represent a pain risk phenotype for this population.

Indexed as

Cardiometabolic Risk FactorsAdultAllostasisAmerican Indian or Alaska NativeCentral Nervous System SensitizationChronic PainFemaleHumansLatent Class AnalysisMaleMiddle AgedNociceptionOklahomaPain ThresholdAllostatic loadcentral sensitizationdescending inhibitionethnic differencespain modulationquantitative sensory testing

Identifiers

PMID34033965
PMCPMC8578174
OpenAlexW3165068086

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.