Evidence map›Paper›PMID 34033922›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022

Ileal Pouch Anal Anastomosis for the Management of Ulcerative Colitis Is Associated With Significant Disability.

Maia Kayal, Ryan C Ungaro, Alexa Riggs, Kanika Kamal, Manasi Agrawal, Shirley Cohen-Mekelburg, Jordan Axelrad, Adam Faye, Ellen Scherl, Garrett Lawlor and 5 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Increasing Incidence of Pouchitis Between 1996 and 2018: A Population-Based Danish Cohort Study.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Maia KayalDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: maia.kayal@mountsinai.org.
Ryan C UngaroDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Alexa RiggsDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Kanika KamalDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Manasi AgrawalDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Shirley Cohen-MekelburgDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan.
Jordan AxelradDivision of Gastroenterology and Hepatology, NYU Grossman School of Medicine, New York, New York.
Adam FayeDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Ellen ScherlDivision of Gastroenterology and Hepatology, Weill Cornell Medical Center, New York, New York.
Garrett LawlorDivision of Gastroenterology and Hepatology, Columbia University Medical Center, New York, New York.
Keith SultanDivision of Gastroenterology, Hepatology and Nutrition, Northwell Health, Great Neck, New York.
Dana LukinDivision of Gastroenterology and Hepatology, Weill Cornell Medical Center, New York, New York.
Marla C DubinskyDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Jean Frederic ColombelDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
New York Crohn’s and Colitis Organization (NYCCO)
Icahn School of Medicine at Mount Sinai · USCornell University · USColumbia University Irving Medical Center · USNew York University · USNorthwell Health · USUniversity of Michigan · US

Funding

Assessing Predictors of Response to Anti-Tumor Necrosis Alpha Therapy in Early Crohns DiseaseK23DK111995 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI UNGARO, RYAN · 2019 to 2023
$948k
NIDDK NIH HHS K23 DK111995
6 · The paper itself

Abstract

BACKGROUND &

aimsDisability in patients with medically refractory ulcerative colitis (UC) after total proctocolectomy (TPC) with ileal pouch anal anastomosis (IPAA) is not well understood. The aim of this study was to compare disability in patients with IPAA vs medically managed UC, and identify predictors of disability.

methodsThis was a multicenter cross-sectional study performed at 5 academic institutions in New York City. Patients with medically or surgically treated UC were recruited. Clinical and socioeconomic data were collected, and the Inflammatory Bowel Disease Disability Index (IBD-DI) was administered to eligible patients. Predictors of moderate-severe disability (IBD-DI ≥35) were assessed in univariable and multivariable models.

resultsA total of 94 patients with IPAA and 128 patients with medically managed UC completed the IBD-DI. Among patients with IPAA and UC, 35 (37.2%) and 30 (23.4%) had moderate-severe disability, respectively. Patients with IPAA had significantly greater IBD-DI scores compared with patients with medically managed UC (29.8 vs 17.9; P < .001). When stratified by disease activity, patients with active IPAA disease had significantly greater median IBD-DI scores compared with patients with active UC (44.2 vs 30.4; P = .01), and patients with inactive IPAA disease had significantly greater median IBD-DI scores compared with patients with inactive UC (23.1 vs 12.5; P < .001). Moderate-severe disability in patients with IPAA was associated with female sex, active disease, and public insurance.

conclusionsPatients with IPAA have higher disability scores than patients with UC, even after adjustment for disease activity. Female sex and public insurance are predictive of significant disability in patients with IPAA.

Indexed as

ColitisColitis, UlcerativeColonic PouchesInflammatory Bowel DiseasesProctocolectomy, RestorativeCross-Sectional StudiesFemaleHumansPostoperative ComplicationsRetrospective StudiesDisabilityPouchUlcerative Colitis

Identifiers

PMID34033922
PMCPMC9638721
OpenAlexW3164631516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.