Evidence map›Paper›PMID 34033913›Full record

ArticleNeuroImage2021

Inter-subject and inter-parcellation variability of resting-state whole-brain dynamical modeling.

Oleksandr V Popovych, Kyesam Jung, Thanos Manos, Sandra Diaz-Pier, Felix Hoffstaedter, Jan Schreiber, B T Thomas Yeo, Simon B Eickhoff

Abstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  19. Pattern of frustration formation in the functional brain network.Network neuroscience (Cambridge, Mass.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oleksandr V PopovychInstitute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine, University Duesseldorf, Duesseldorf, Germany. Electronic address: o.popovych@fz-juelich.de.
Kyesam JungInstitute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine, University Duesseldorf, Duesseldorf, Germany.
Thanos ManosInstitute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine, University Duesseldorf, Duesseldorf, Germany; Laboratoire de Physique Théorique et Modélisation, CY Cergy Paris Université, CNRS, UMR 8089, Cergy-Pontoise cedex 95302, France.
Sandra Diaz-PierInstitute for Advanced Simulation, Juelich Supercomputing Centre (JSC), Research Centre Juelich, Juelich, Germany.
Felix HoffstaedterInstitute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine, University Duesseldorf, Duesseldorf, Germany.
Jan SchreiberInstitute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Juelich, Germany.
B T Thomas YeoCentre for Sleep and Cognition, Centre for Translational MR Research & N.1 Institute for Health, National University of Singapore, Singapore; Department of Electrical and Computer Engineering, National University of Singapore, Singapore; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; Integrative Sciences and Engineering Programme (ISEP), Singapore.
Simon B EickhoffInstitute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine, University Duesseldorf, Duesseldorf, Germany.

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Modern approaches to investigate complex brain dynamics suggest to represent the brain as a functional network of brain regions defined by a brain atlas, while edges represent the structural or functional connectivity among them. This approach is also utilized for mathematical modeling of the resting-state brain dynamics, where the applied brain parcellation plays an essential role in deriving the model network and governing the modeling results. There is however no consensus and empirical evidence on how a given brain atlas affects the model outcome, and the choice of parcellation is still rather arbitrary. Accordingly, we explore the impact of brain parcellation on inter-subject and inter-parcellation variability of model fitting to empirical data. Our objective is to provide a comprehensive empirical evidence of potential influences of parcellation choice on resting-state whole-brain dynamical modeling. We show that brain atlases strongly influence the quality of model validation and propose several variables calculated from empirical data to account for the observed variability. A few classes of such data variables can be distinguished depending on their inter-subject and inter-parcellation explanatory power.

Indexed as

Atlases as TopicModels, TheoreticalBrainComputer SimulationConnectomeHumansMagnetic Resonance ImagingReproducibility of ResultsBrain atlasBrain connectomeModel validationResting-state brain dynamicsSimulationsWhole-brain model

Identifiers

PMID34033913
PMCPMC8271096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.