Evidence map›Paper›PMID 34033836›Full record

ReviewProgress in biophysics and molecular biology2021

Coronavirus disease 2019 (COVID-19): Biophysical and biochemical aspects of SARS-CoV-2 and general characteristics.

Günnur Güler, Helin Özdemir, Dilara Omar, Gül Akdoğan

Abstract readReview
In one paragraph

Review in Progress in biophysics and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Günnur GülerDepartment of Biomedical Engineering, Izmir University of Economics, 35330 Izmir, Turkey. Electronic address: gunnur.guler@ieu.edu.tr.
Helin ÖzdemirFaculty of Medicine, Izmir University of Economics, 35330 Izmir, Turkey.
Dilara OmarFaculty of Medicine, Izmir University of Economics, 35330 Izmir, Turkey.
Gül AkdoğanFaculty of Medicine, Izmir University of Economics, 35330 Izmir, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease (COVID-19) arises from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is an enveloped RNA virus. COVID-19 has rapidly spread throughout the world by infecting more than 143 million people and causing 3.04 million deaths worldwide by 22 April 2021, confirmed by the World Health Organization. It caused great concern and pandemic all over the world, therewithal there has not been found any specific and efficient treatment yet. In the current review, we aimed to define the biophysical and biochemical aspects of SARS-CoV-2, including renin-angiotensin-system, cytokine storms, receptor binding, protein structural and functional features, molecular interactions, and conformational changes that take place during viral attachment and entering into human cells. It was also aimed to highlight the general hallmarks of COVID-19, including treatment strategies, diagnosis and even prevention. Thus, this review will serve as an updated comprehensive body of information and discussion on COVID-19 and will help the molecular scientists, biophysicists, clinicians, as well as medical engineers. Thereby, further understanding of COVID-19 will provide novel insights and advances in development of therapeutic potentials and vaccine alternatives as well as in detection of specific targets for diagnosis.

Indexed as

Angiotensin-Converting Enzyme 2AnimalsCell Membrane PermeabilityCOVID-19COVID-19 Drug TreatmentCytokinesHumansPandemicsProtein BindingProtein ConformationRenin-Angiotensin SystemSARS-CoV-2Spike Glycoprotein, CoronavirusStructure-Activity RelationshipAngiotensin-Converting Enzyme 2CytokinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ACE2ConformationCoronavirusCOVID-19SARS-CoV-2Spike protein

Identifiers

PMID34033836
PMCPMC8142027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.