ArticlePLoS computational biology2021
Global disruption in excitation-inhibition balance can cause localized network dysfunction and Schizophrenia-like context-integration deficits.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Atypical Use of Visuospatial Context in Psychotic Psychopathology: A Meta-analysis.Schizophrenia bulletin · 2025Pooled it
- Mesocorticostriatal Reinforcement Learning of State Representation and Value with Implications for the Mechanisms of Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Working memory processes and the histamine-3 receptor in schizophrenia: a [Psychopharmacology · 2025Article
- The Relationship Among Range Adaptation, Social Anhedonia, and Social Functioning: A Combined Magnetic Resonance Spectroscopy and Resting-State fMRI Study.Schizophrenia bulletin · 2025Article
- Clarifying Cognitive Control Deficits in Psychosis via Drift Diffusion Modeling and Attractor Dynamics.Schizophrenia bulletin · 2024Article
- Human stem cell-based models to study synaptic dysfunction and cognition in schizophrenia: A narrative review.Schizophrenia research · 2024Review
- Prenatal Exposure to MAM Impairs mPFC and Hippocampal Inhibitory Function in Mice during Adolescence and Adulthood.eNeuro · 2024Article
- Adaptive coding of reward in schizophrenia, its change over time and relationship to apathy.Brain : a journal of neurology · 2024Article
- Gamma Oscillations and Potassium Channel Modulation in Schizophrenia: Targeting GABAergic Dysfunction.Clinical EEG and neuroscience · 2024Article
- Article
- Measuring excitation-inhibition balance through spectral components of local field potentials.bioRxiv : the preprint server for biology · 2024Article
- Next-Generation Proteomics of Brain Extracellular Vesicles in Schizophrenia Provide New Clues on the Altered Molecular Connectome.Biomedicines · 2024Article
- Increased noise relates to abnormal excitation-inhibition balance in schizophrenia: a combined empirical and computational study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders.Neuronal signaling · 2023Review
- Article
- Etiopathogenic Models of Psychosis Spectrum Illnesses Must Resolve Four Key Features.Biological psychiatry · 2022Review
- Article
- Long-interval intracortical inhibition in primary motor cortex related to working memory in middle-aged adults.Frontiers in psychology · 2022Article
- Neural circuit function redundancy in brain disorders.Current opinion in neurobiology · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Poor context integration, the process of incorporating both previous and current information in decision making, is a cognitive symptom of schizophrenia. The maintenance of the contextual information has been shown to be sensitive to changes in excitation-inhibition (EI) balance. Many regions of the brain are sensitive to EI imbalances, however, so it is unknown how systemic manipulations affect the specific regions that are important to context integration. We constructed a multi-structure, biophysically-realistic agent that could perform context-integration as is assessed by the dot pattern expectancy task. The agent included a perceptual network, a memory network, and a decision making system and was capable of successfully performing the dot pattern expectancy task. Systemic manipulation of the agent's EI balance produced localized dysfunction of the memory structure, which resulted in schizophrenia-like deficits at context integration. When the agent's pyramidal cells were less excitatory, the agent fixated upon the cue and initiated responding later than the default agent, which were like the deficits one would predict that individuals on the autistic spectrum would make. This modelling suggests that it may be possible to parse between different types of context integration deficits by adding distractors to context integration tasks and by closely examining a participant's reaction times.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.