Observational studyAmerican journal of respiratory and critical care medicine2021
Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment.
Abstract readMulticenter StudyObservational Study
In one paragraph
Observational study in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Use of Computed Tomography Densitometry for the Assessment of Emphysema in Clinical Trials: A Position Paper from the Fleischner Society.American journal of respiratory and critical care medicine · 2025Pooled it
- The estrogen-progestogen-oxidative stress network in uterine fibroids: mechanistic insights and therapeutic opportunities.Redox report : communications in free radical research · 2026Review
- Defective alveolar regeneration in emphysema: identifying dysfunctional cellular crosstalk and novel therapeutic opportunities for tissue repair.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026Review
- Type 2 Diabetes and the Lung - Cause and Consequence.Current diabetes reports · 2026Review
- Regenerative therapeutics for chronic obstructive pulmonary disease.Pharmacological reviews · 2026Review
- Cardiometabolic Comorbidities in COPD: Focus on Diabetes, GLP-1 Receptor Agonists, SGLT-2 Inhibitors and Antidiabetic Drugs.Journal of clinical medicine · 2026Review
- New approaches to uncover COPD pathobiology and develop therapies.JCI insight · 2026Review
- Treatment of chronic obstructive pulmonary disease: current pipeline and new opportunities.Nature reviews. Drug discovery · 2026Review
- Breaking barriers in pulmonary health of patients with metabolic diseases: senolytics and beyond.Frontiers in aging · 2026Review
- Immune-metabolic positive feedback model in COPD: cross-mechanisms and potential intervention strategies.Frontiers in cell and developmental biology · 2026Review
- Mucus plugs on CT and small airway pathology in COPD.ERJ open research · 2025Article
- Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis.Microbiology spectrum · 2025Article
- Post-COPD: Can Emphysema Be Repaired?American journal of respiratory and critical care medicine · 2025Article
- Current landscape of the immunoproteasome: implications for disease and therapy.Cell death discovery · 2025Review
- Metformin effects on respiratory and metabolic outcomes in asthma and metabolic syndrome: a double-blind, randomized, placebo-controlled clinical trial.Annals of medicine and surgery (2012) · 2025Article
- Senotherapy for chronic lung disease.Pharmacological reviews · 2025Review
- Association of novel antihyperglycaemic drugsERJ open research · 2025Article
- Exploring the Effects of Metformin on the Body via the Urine Proteome.Biomolecules · 2025Article
- Proteome Profiling of Red Blood Cells from Patients with COPD Links Proteasome Activation with Abnormal Cell Morphology and Function.International journal of chronic obstructive pulmonary disease · 2025Article
Corrections and comments
- Commented on by
Authors and funding
28 authors.
Francesca PolverinoAsthma and Airway Disease Research Center and.ORCID 0000-0001-9686-5698
Tianshi David WuSection of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, Texas.
Joselyn Rojas-QuinteroDivision of Pulmonary and Critical Care Medicine and.
Xiaoyun WangClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, Georgia.ORCID 0000-0002-9900-740X
Jonathan MayoAsthma and Airway Disease Research Center and.
Michael TomchaneyAsthma and Airway Disease Research Center and.
Judy TramAsthma and Airway Disease Research Center and.
Samuel PackardAsthma and Airway Disease Research Center and.
Duo ZhangCollege of Pharmacy, and.
Kristan H ClevelandCollege of Pharmacy, and.
Elizabeth Cordoba-LanusServicio de Neumología, Unidad de Investigación, Hospital Universitario La Candelaria, Santa Cruz de Tenerife, Tenerife, Spain.
Caroline A OwenDivision of Pulmonary and Critical Care Medicine and.
Ashraf FawzyDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Greg L KinneyDepartment of Epidemiology, Colorado School of Public Health, Aurora, Colorado.
Craig P HershChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-1342-4334
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Kevin DoubledayDivision of Endocrinology, Department of Medicine.
Maor SaulerPulmonary Division, School of Medicine, Yale University, New Haven, Connecticut.
Yohannes TesfaigziDivision of Pulmonary and Critical Care Medicine and.ORCID 0000-0002-3997-5839
Julie G LedfordAsthma and Airway Disease Research Center and.
Ciro CasanovaServicio de Neumología, Unidad de Investigación, Hospital Universitario La Candelaria, Santa Cruz de Tenerife, Tenerife, Spain.
Jaroslaw ZmijewskiPulmonary and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, Alabama; and.
John KonhilasDepartment of Physiology, University of Arizona, Tucson, Arizona.
Paul R LanglaisDivision of Endocrinology, Department of Medicine.
Rick SchnellmannCollege of Pharmacy, and.
Irfan RahmanDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, New York.
Meredith McCormackDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Bartolome CelliDivision of Pulmonary and Critical Care Medicine and.
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MEarly Origins of Chronic Lung Disease: Outcomes into the Fifth Decade of LifeR01HL132523 · NHLBI · UNIVERSITY OF ARIZONA · PI Stefano Guerra, Fernando D Martinez · 2016 to 2026
$15.1MTraining in Environmental Toxicology of Human DiseaseT32ES007091 · NIEHS · UNIVERSITY OF ARIZONA · PI Nathan J Cherrington · 1985 to 2026
$10.7MThe role of obesity in biological responses to particulate matter in miceP50ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$4.8MAMPK in the Development and Resolution of Lung FibrosisR01HL139617 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Victor J. Thannickal, Jaroslaw Waldemar Zmijewski · 2019 to 2026
$4.4MDefining mechanisms of CC16 on epithelial-driven host responses to pathogensR01HL142769 · NHLBI · UNIVERSITY OF ARIZONA · PI Julie Gunnells Ledford · 2019 to 2026
$4.2MThe Environmental Assessments Core (FSC)P50MD010431 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$3.5MB cell-adaptive Immune Profile in Emphysema-predominant COPDR01HL149744 · NHLBI · UNIVERSITY OF ARIZONA · PI POLVERINO, FRANCESCA · 2020 to 2024
$3.4MRole of MIF and CD74 in the pathogenesis of emphysemaR01HL155948 · NHLBI · YALE UNIVERSITY · PI BUCALA, RICHARD J, SAULER, MAOR · 2021 to 2025
$3.4MMIF and DNA repair in the emphysematous lungK08HL135402 · NHLBI · YALE UNIVERSITY · PI SAULER, MAOR · 2017 to 2021
$842kNCATS NIH HHS UL1 TR001863NHLBI NIH HHS K08 HL135402NHLBI NIH HHS R01 HL132523NHLBI NIH HHS R01 HL139617NHLBI NIH HHS R01 HL142769NHLBI NIH HHS R01 HL149744NHLBI NIH HHS R01 HL155948NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIEHS NIH HHS P50 ES018176NIEHS NIH HHS T32 ES007091NIMHD NIH HHS P50 MD010431
Abstract
PubMed holds no abstract for this paper.
Indexed as
AgedAged, 80 and overAnimalsBiomarkersCigarette SmokingDisease ProgressionFemaleFollow-Up StudiesHumansMaleMetforminMiceMice, Inbred C57BLMiddle AgedProtective AgentsPulmonary Disease, Chronic ObstructiveBiomarkersMetforminProtective Agentsagingchronic obstructive pulmonary diseasecigarette smokecomorbiditiesmetformin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.