Evidence map›Paper›PMID 34033143›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Mechanical overload-induced muscle-derived extracellular vesicles promote adipose tissue lipolysis.

Ivan J Vechetti, Bailey D Peck, Yuan Wen, R Grace Walton, Taylor R Valentino, Alexander P Alimov, Cory M Dungan, Douglas W Van Pelt, Ferdinand von Walden, Björn Alkner and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
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  11. Physical exercise in liver diseases.Hepatology (Baltimore, Md.) · 2026
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  14. Adipose-Derived Extracellular Vesicles and Intercellular Crosstalk With Skeletal Muscle: Implications for Sarcopenic Obesity and Metabolic Dysregulation.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Ivan J VechettiDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID 0000-0003-1024-1011
Bailey D PeckCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Yuan WenDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
R Grace WaltonCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Taylor R ValentinoCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Alexander P AlimovCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Cory M DunganCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Douglas W Van PeltCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Ferdinand von WaldenDivision of Neuropediatrics, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Björn AlknerDivision of Neuropediatrics, Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Charlotte A PetersonCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA.
John J McCarthyCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA.
University of Kentucky · USUniversity of Nebraska–Lincoln · USKarolinska Institutet · SELinköping University · SE

Funding

Exercise-induced skeletal muscle exosomes promote adipocyte lipolysisR01DK119619 · NIDDK · UNIVERSITY OF KENTUCKY · PI MCCARTHY, JOHN JOSEPH, PETERSON, CHARLOTTE A. · 2018 to 2022
$2.3M
NIDDK NIH HHS R01 DK119619
6 · The paper itself

Abstract

How regular physical activity is able to improve health remains poorly understood. The release of factors from skeletal muscle following exercise has been proposed as a possible mechanism mediating such systemic benefits. We describe a mechanism wherein skeletal muscle, in response to a hypertrophic stimulus induced by mechanical overload (MOV), released extracellular vesicles (EVs) containing muscle-specific miR-1 that were preferentially taken up by epidydimal white adipose tissue (eWAT). In eWAT, miR-1 promoted adrenergic signaling and lipolysis by targeting Tfap2α, a known repressor of Adrβ3 expression. Inhibiting EV release prevented the MOV-induced increase in eWAT miR-1 abundance and expression of lipolytic genes. Resistance exercise decreased skeletal muscle miR-1 expression with a concomitant increase in plasma EV miR-1 abundance, suggesting a similar mechanism may be operative in humans. Altogether, these findings demonstrate that skeletal muscle promotes metabolic adaptations in adipose tissue in response to MOV via EV-mediated delivery of miR-1.

Indexed as

ExerciseLipolysisStress, MechanicalAdipose Tissue, WhiteAdolescentAdultAnimalsExtracellular VesiclesFemaleGene Expression RegulationHumansMaleMiceMice, Inbred C57BLMicroRNAsMiddle AgedMicroRNAsMIRN1 microRNA, humanTFAP2A protein, humanTranscription Factor AP-2adipose tissueextracellular vesicleslipolysismicroRNAsskeletal muscle

Identifiers

PMID34033143
PMCPMC8607211
OpenAlexW3164680687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.