Evidence map›Paper›PMID 34033061›Full record

ReviewMolecular neurobiology2021

The Intersection of Parkinson's Disease, Viral Infections, and COVID-19.

Benjamin Rosen, Alberim Kurtishi, Gonzalo R Vazquez-Jimenez, Simon Geir Møller

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Long COVID: From olfactory dysfunctions to viral Parkinsonism.World journal of otorhinolaryngology - head and neck surgery · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Benjamin RosenDepartment of Biological Sciences, St. John's University, New York, NY, 11439, USA.
Alberim KurtishiDepartment of Biological Sciences, St. John's University, New York, NY, 11439, USA.
Gonzalo R Vazquez-JimenezDepartment of Biological Sciences, St. John's University, New York, NY, 11439, USA.
Simon Geir MøllerDepartment of Biological Sciences, St. John's University, New York, NY, 11439, USA. mollers@stjohns.edu.ORCID http://orcid.org/0000-0002-0460-3592
St. John's University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of human COVID-19, not only causes flu-like symptoms and gut microbiome complications but a large number of infected individuals also experience a host of neurological symptoms including loss of smell and taste, seizures, difficulty concentrating, decreased alertness, and brain inflammation. Although SARS-CoV-2 infections are not more prevalent in Parkinson's disease patients, a higher mortality rate has been reported not only associated with older age and longer disease duration, but also through several mechanisms, such as interactions with the brain dopaminergic system and through systemic inflammatory responses. Indeed, a number of the neurological symptoms seen in COVID-19 patients, as well as the alterations in the gut microbiome, are also prevalent in patients with Parkinson's disease. Furthermore, biochemical pathways such as oxidative stress, inflammation, and protein aggregation have shared commonalities between Parkinson's disease and COVID-19 disease progression. In this review, we describe and compare the numerous similarities and intersections between neurodegeneration in Parkinson's disease and RNA viral infections, emphasizing the current SARS-CoV-2 global health crisis.

Indexed as

Gastrointestinal MicrobiomeSARS-CoV-2Agedalpha-SynucleinCognition DisordersCOVID-19CytokinesDietDisease ProgressionDysbiosisHumansInflammationMetals, HeavyModels, NeurologicalNerve DegenerationOlfactory Bulbalpha-SynucleinCytokinesMetals, HeavyReactive Oxygen SpeciesCOVID-19Gut microbiomeInflammationOlfactory bulbParkinson’s diseaseViral infections

Identifiers

PMID34033061
PMCPMC8143990
OpenAlexW3165001112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.