Evidence map›Paper›PMID 34032908›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2021

Association between obstructive sleep apnea and thyroid cancer incidence: a national health insurance data study.

Ji Ho Choi, Jae Yong Lee, Young Chang Lim, Jin Kook Kim, Kyung Do Han, Jae Hoon Cho

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  6. Association between obstructive sleep apnea and thyroid cancer incidence: a national health insurance data study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ji Ho ChoiDepartment of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea.
Jae Yong LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea.
Young Chang LimDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konkuk University College of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, 143-729, Korea.
Jin Kook KimDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konkuk University College of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, 143-729, Korea.
Kyung Do HanDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, Korea.
Jae Hoon ChoDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konkuk University College of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, 143-729, Korea. jaehoon@kuh.ac.kr.ORCID http://orcid.org/0000-0002-2243-7428
Konkuk University · KRSoonchunhyang University · KRSoongsil University · KR

Funding

National Reseach Foundation of Korea NRF-2016R1C1B2015652
6 · The paper itself

Abstract

purposeLittle is known about the incidence of thyroid cancer in patients with obstructive sleep apnea (OSA). This study aimed to evaluate whether OSA is associated with the incidence of thyroid cancer based on the Korea National Health Insurance Service (KNHIS) database.

methodsThis study was designed as a retrospective cohort data analysis of the KNHIS dataset. A total of 198,574 patients who were over 20 years of age and had been newly diagnosed with OSA between 2007 and 2014 were enrolled. A control group of 992,870 individuals was selected based on propensity score matching by age and sex. The mean follow-up duration was 4.5 ± 2.3 years. The primary endpoint was the incidence of newly diagnosed thyroid cancer.

resultsThe hazard ratio (HR) for thyroid cancer incidence among OSA patients compared to the control was 1.72 (95% confidence interval [CI] 1.60-1.84) based on Model 1 (not adjusted by any covariate) and 1.64 (95% CI 1.53-1.76) based on Model 2 (adjusted by income level, diabetes, hypertension, and dyslipidemia). Thyroid cancer incidence was significantly higher in male patients (HR = 1.93, 95% CI 1.74-2.12) than female ones (HR = 1.39, 95% CI 1.26-1.54). When compared by age, the HR of thyroid cancer was higher in middle-aged (40 ≤ age < 65 years) patients (HR = 1.68, 95% CI 1.55-1.83) than in young (20 ≤ age < 40 years, HR = 1.53, 95% CI 1.32-1.77) or old (65 ≤ age, HR = 1.28, 95% CI 0.94-1.74) patients.

conclusionOSA may increase the risk of developing thyroid cancer, especially in middle-aged men.

Indexed as

Sleep Apnea, ObstructiveThyroid NeoplasmsAdultAgedFemaleHumansIncidenceMaleMiddle AgedNational Health ProgramsRepublic of KoreaRetrospective StudiesRisk FactorsMiddle-agedObstructive sleep apneaRisk factorThyroid cancer

Identifiers

PMID34032908
OpenAlexW3164795214

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.