Evidence map›Paper›PMID 34032608›Full record

ArticleAging2021

Role of LINC01592 in TGF-β1-induced epithelial-mesenchymal transition of retinal pigment epithelial cells.

Ying Su, Ziyan Tang, Feng Wang

Abstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ying SuDepartment of Ophthalmology, The First Hospital of Harbin Medical University, Harbin, China.
Ziyan TangDepartment of Ophthalmology, The First Hospital of Harbin Medical University, Harbin, China.
Feng WangDepartment of Ophthalmology, The First Hospital of Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulation of long-chain non-coding RNA01592 (LINC01592) in the process of transforming retinal pigment epithelial (RPE) cells into mesenchymal cells following induction by transforming growth factor beat 1 (TGF-β1) was investigated by interfering with LINC01592 expression in human RPE (hRPE) cells. LINC01592 expression in hRPE cells was significantly increased following treatment with 10 ng/mL TGF-β1 for 48 h. Expression of E-cadherin and Snail were decreased in hRPE cells following induction with TGF-β1 compared with the control group (

Indexed as

Biomarkers, TumorCell MovementCell ProliferationCell ShapeEpithelial CellsEpithelial-Mesenchymal TransitionGene Knockdown TechniquesHumansRetinal Pigment EpitheliumRNA, Long NoncodingSnail Family Transcription FactorsTransforming Growth Factor beta1Up-RegulationBiomarkers, TumorRNA, Long NoncodingSnail Family Transcription FactorsTransforming Growth Factor beta1epithelial-mesenchymal transitionlong-chain non-coding RNAretinal pigment epithelial cells

Identifiers

PMID34032608
PMCPMC8202905

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.