Evidence map›Paper›PMID 34032419›Full record

ArticleACS applied materials & interfaces2021

Bio-Inspired Amphoteric Polymer for Triggered-Release Drug Delivery on Breast Cancer Cells Based on Metal Coordination.

Pin-Chun Chen, James J Lai, Chun-Jen Huang

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Pin-Chun ChenDepartment of Chemical & Materials Engineering, National Central University, Jhong-Li, Taoyuan 320, Taiwan.
James J LaiDepartment of Bioengineering, University of Washington, Seattle, Washington 98195, United States.
Chun-Jen HuangDepartment of Chemical & Materials Engineering, National Central University, Jhong-Li, Taoyuan 320, Taiwan.ORCID https://orcid.org/0000-0001-9832-5812
Chung Yuan Christian University · TWNational Central University · TWUniversity of Washington · US

Funding

MicroRNAs in CNS-derived extracellular microvesicles as peripheral blood biomarkers for Alzheimer diseaseR01AG061383 · NIA · UNIVERSITY OF WASHINGTON · PI SHI, MIN · 2019 to 2023
$3.4M
Characterization and quantification of CNS cell specific extracellular microvesicles in bloodR33MH118160 · NIMH · UNIVERSITY OF WASHINGTON · PI SHI, MIN · 2020 to 2022
$2.0M
Characterization and quantification of CNS cell specific extracellular microvesicles in bloodR21MH118160 · NIMH · UNIVERSITY OF WASHINGTON · PI STEWART, TESSANDRA · 2018 to 2019
$424k
NIA NIH HHS R01 AG061383NIMH NIH HHS R21 MH118160NIMH NIH HHS R33 MH118160
6 · The paper itself

Abstract

Nanoscale coordination polymers are promising vehicles for anticancer drug delivery because their surface composition and particle size can be tuned to exploit the enhanced permeability and retention effect, and their reversible interaction with metal cations enables triggered drug release at the tumor site. Here, we develop a novel nanoscale coordination polymer using the diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)-

Indexed as

Drug Delivery SystemsDrug LiberationAntineoplastic AgentsCell SurvivalCurcuminDrug CarriersFemaleHumansHydrogen-Ion ConcentrationMetalsNanoparticlesPolyethylene GlycolsPolymersTriple Negative Breast NeoplasmsTumor Cells, CulturedAntineoplastic AgentsCurcuminDrug CarriersMetalsPolyethylene GlycolsPolymersanticancer drug deliverydiblock zwitterionic copolymernanoscale coordination polymerpolymeric colloidtriggered release

Identifiers

PMID34032419
PMCPMC8381753
OpenAlexW3165513021

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.