ArticleBrain and behavior2021
Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: Comparison in younger and older adults.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05131217 (Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults
Who cites it
12 citing papers in PubMed.
- Hyperoxic cerebral vasoconstriction in healthy humans: global, lobe, and regions of interest.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Sex differences in cerebrovascular function across an aerobic exercise intervention in older adults using MRI: Results from the Brain in Motion study.Physiological reports · 2026Article
- Transcranial Doppler ultrasound validation of BOLD-fMRI cerebral blood flow relationship.Magnetic resonance in medicine · 2026Article
- The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment, the Excersion-VCI randomised controlled clinical trial.Cerebral circulation - cognition and behavior · 2025Article
- Longitudinal assessment of transcranial Doppler imaging in children with sickle cell disease without neurological symptoms.BMC pediatrics · 2024Article
- Cardiorespiratory Fitness and Sleep, but not Physical Activity, are Associated with Functional Connectivity in Older Adults.Sports medicine - open · 2024Article
- Article
- Dobutamine-induced alternations in cerebral blood flow of healthy adults: a 3D pseudocontinuous arterial spin labeling study.BMC medicine · 2023Article
- Cerebral hemodynamics comparison using transcranial doppler ultrasound and 4D flow MRI.Frontiers in physiology · 2023Article
- Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: Comparison in younger and older adults.Brain and behavior · 2021Article
- Cerebral Vasoreactivity Changes Over Time in Patients With Different Clinical Manifestations of Cerebral Small Vessel Disease.Frontiers in aging neuroscience · 2021Article
- Contrasting Measures of Cerebrovascular Reactivity Between MRI and Doppler: A Cross-Sectional Study of Younger and Older Healthy Individuals.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionResting cerebral blood flow (CBF) and perfusion measures have been used to determine brain health. Studies showing variation in resting CBF with age and fitness level using different imaging approaches have produced mixed findings. We assess the degree to which resting CBF measures through transcranial Doppler (TCD) and arterial spin labeling (ASL) MRI provide complementary information in older and younger, fit and unfit cohorts.
methodsThirty-five healthy volunteers (20 younger: 24 ± 7y; 15 older: 66 ± 7y) completed two experimental sessions (TCD/MRI). Aging and fitness effects within and between imaging modalities were assessed.
resultsMiddle cerebral artery blood velocity (MCAv, TCD) was lower and transit time (MRI) slower in older compared with younger participants (p < .05). The younger group had higher gray matter cerebral perfusion (MRI) than the older group, albeit not significantly (p = .13). Surprisingly, fitness effects in the younger group (decrease/increase in MCAv/transit time with fitness, respectively) opposed the older group (increase/decrease in MCAv/transit time). Whole cohort transit times correlated with MCAv (r=-0.63; p < .05), whereas tissue perfusion did not correlate with TCD measures.
conclusionTCD and MRI modalities provide complementary resting CBF measures, with similar effects across the whole cohort and between subgroups (age/fitness) if metrics are comparable (e.g., velocity [TCD] versus transit time [MRI]).
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