Evidence map›Paper›PMID 34032285›Full record

ArticleFEBS letters2021

Class A G protein-coupled receptors assemble into functional higher-order hetero-oligomers.

Xianlong Gao, Garrett A Enten, Anthony J DeSantis, Matthias Majetschak

Open access · greenAbstract read
In one paragraph

Article in FEBS letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Activation of Chemokine (C-C Motif) Receptor 1 Modulates αJournal of the American Heart Association · 2025
    Article
  4. Article
  5. Article
  6. αPharmacological research · 2023
    Article
  7. Heteromerization between αFEBS letters · 2022
    Article
  8. αProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xianlong GaoDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Garrett A EntenDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Anthony J DeSantisDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Matthias MajetschakDepartment of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.ORCID 0000-0002-4086-0887
University of South Florida · US

Funding

Contributions of vascular chemokine receptors to cardiovascular function after traumatic-hemorrhagic shockR01GM139811 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI MAJETSCHAK, MATTHIAS · 2020 to 2023
$1.7M
Molecular mechanisms regulating leukocyte traffickingR21AI139827 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI MAJETSCHAK, MATTHIAS · 2019 to 2020
$411k
Sensitization of vascular function by ethanolR21AA025750 · NIAAA · UNIVERSITY OF SOUTH FLORIDA · PI MAJETSCHAK, MATTHIAS · 2018 to 2019
$395k
NIAAA NIH HHS R21 AA025750NIAID NIH HHS R21 AI139827NIGMS NIH HHS R01 GM139811
6 · The paper itself

Abstract

Although class A seven-transmembrane helix (7TM) receptor hetero-oligomers have been proposed, information on the assembly and function of such higher-order hetero-oligomers is not available. Utilizing bioluminescence resonance energy transfer (BRET), bimolecular luminescence/fluorescence complementation (BiLC/BiFC), and BiLC/BiFC BRET in HEK293T cells, we provide evidence that chemokine (C-X-C motif) receptor 4, atypical chemokine receptor 3, α

Indexed as

Bacterial ProteinsChemokine CXCL12Fluorescence Resonance Energy TransferGene ExpressionGenes, ReporterHEK293 CellsHumansKineticsLuciferasesLuminescent ProteinsPlasmidsProtein BindingProtein ConformationProtein Interaction Domains and MotifsProtein MultimerizationReceptors, Adrenergic, alpha-1ACKR3 protein, humanADRA1A protein, humanAVPR1A protein, humanBacterial ProteinsChemokine CXCL12CXCL12 protein, humanCXCR4 protein, humanLuciferasesLuminescent ProteinsReceptors, Adrenergic, alpha-1Receptors, CXCRReceptors, CXCR4Receptors, VasopressinRecombinant Fusion Proteinsyellow fluorescent protein, BacteriaACKR3AVPR1Aɑ1-adrenergic receptorCXCR4receptor dimerreceptor hetero-oligomerization

Identifiers

PMID34032285
PMCPMC8316310
OpenAlexW3164168637

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.