ArticleBiotechnology and bioengineering2021
Analysis of filtration behavior using integrated column chromatography followed by virus filtration.
Article in Biotechnology and bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Development of a Small-Scale Continuous Virus Filtration Model That Incorporates Inline Spiking and Mixing.Biotechnology and bioengineering · 2025Article
- Review
- Integration of a perfusion reactor and continuous precipitation in an entirely membrane-based process for antibody capture.Engineering in life sciences · 2023Article
- Analysis of filtration behavior using integrated column chromatography followed by virus filtration.Biotechnology and bioengineering · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated filtration behavior and virus removal capability for a monoclonal antibodies (mAb) and plasma IgG under constant flow rate directly following flow-through column chromatography in an integrated process. mAb solution with quantified host cell protein (HCP) content processed in flow-through mode on in-series mixed-mode AEX and modified CEX columns connected to the Planova BioEX filter (pool-less) achieved HCP logarithmic reduction value (LRV) of 2.3 and 93.9% protein recovery, demonstrating comparable or higher HCP LRV with high protein recovery compared to previous reports. For 5-15 mg/ml plasma IgG run to 100 L/m
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