ReviewNatural product reports2021
Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity.
Review in Natural product reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A Wagner-Meerwein-Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles.Angewandte Chemie (International ed. in English) · 2026Article
- Curation of Mass Spectrometry Reference Data for Improved Identification and Dereplication of Cyanobacterial Specialized Metabolites.Journal of natural products · 2026Article
- The Paradox of Antimalarial Terpenoid Isonitrile Biosynthesis Explained. Proposal of Cyanoformate as an NC Delivery Vector.Journal of natural products · 2025Article
- Hapalindole Q suppresses autophagosome-lysosome fusion by promoting YAP1 degradation via chaperon-mediated autophagy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- CspACS catalysis · 2024Article
- Biomedical engineering utilizing living photosynthetic cyanobacteria and microalgae: Current status and future prospects.Materials today. Bio · 2024Review
- Biosynthesis of isonitrile lipopeptides.Current opinion in chemical biology · 2024Review
- A NovelMolecules (Basel, Switzerland) · 2024Article
- Actinobacterial chalkophores: the biosynthesis of hazimycins.The Journal of antibiotics · 2024Article
- Crystal Clear: Decoding Isocyanide Intermolecular Interactions through Crystallography.The Journal of organic chemistry · 2024Article
- Cyanobacteria: A Promising Source of Antifungal Metabolites.Marine drugs · 2023Review
- Identification of Isonitrile-Containing Natural Products in Complex Biological Matrices through Ligation with Chlorooximes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate.Nature communications · 2022Article
- Structure and Biosynthesis of Desmamides A-C, Lipoglycopeptides from the Endophytic CyanobacteriumJournal of natural products · 2022Review
- Recent Advances in the Synthesis of Marine-Derived Alkaloids via Enzymatic Reactions.Marine drugs · 2022Review
- Cyanobacterial secondary metabolites towards improved commercial significance through multiomics approaches.World journal of microbiology & biotechnology · 2022Review
- Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis.ACS catalysis · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Covering: 1984 up to the end of 2020Hapalindoles, fischerindoles, ambiguines and welwitindolinones are all members of a class of indole alkaloid natural products that have been isolated from the Stigonematales order of cyanobacteria. These compounds possess a polycyclic ring system, unique functional groups and various stereo- and regiochemical isomers. Since their initial isolation in 1984, they have been explored as potential therapeutics due to their wide variety of biological activities. Although numerous groups have pursued total syntheses of these densely functionalized structures, hapalindole biosynthesis has only recently been unveiled. Several groups have uncovered a wide range of novel enzymes that catalyze formation and tailoring of the hapalindole-type metabolites. In this article, we provide an overview of these natural products, their biological activities, highlight general synthetic routes, and provide an extensive review on the surprising biosynthetic processes leading to these structurally diverse metabolites.
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