Evidence map›Paper›PMID 34032216›Full record

ArticleeLife2021

Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation.

Robert J Huebner, Abdul Naseer Malmi-Kakkada, Sena Sarıkaya, Shinuo Weng, D Thirumalai, John B Wallingford

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Article
  12. Article
  13. Conserved physical mechanisms of cell and tissue elongation.Development (Cambridge, England) · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Mechanics of cell-cell junctions.Biophysical journal · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Robert J Huebner *Department of Molecular Biosciences, University of Texas, Austin, United States.ORCID 0000-0001-8778-9689
Abdul Naseer Malmi-Kakkada *Department of Chemistry, University of Texas, Austin, United States.ORCID 0000-0002-5429-4652
Sena SarıkayaDepartment of Molecular Biosciences, University of Texas, Austin, United States.ORCID 0000-0001-5008-2065
Shinuo WengDepartment of Molecular Biosciences, University of Texas, Austin, United States.ORCID 0000-0001-7932-913X
D ThirumalaiDepartment of Chemistry, University of Texas, Austin, United States.ORCID 0000-0003-1801-5924
John B WallingfordDepartment of Molecular Biosciences, University of Texas, Austin, United States.ORCID 0000-0002-6280-8625
The University of Texas at Austin · USAugusta University · US

Funding

Molecular and cell biological basis of convergent extensionR01HD099191 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI John B Wallingford · 2020 to 2026
$2.7M
Control of collective cell movement by planar cell polarity signalingR01GM104853 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI WALLINGFORD, JOHN B · 2015 to 2018
$1.3M
Dynamics of vertebrate planar cell polarity proteinsR21HD084072 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI WALLINGFORD, JOHN B · 2015 to 2016
$374k
NICHD NIH HHS R01 HD099191NICHD NIH HHS R21 HD084072NIGMS NIH HHS R01 GM104853
6 · The paper itself

Abstract

Morphogenesis is governed by the interplay of molecular signals and mechanical forces across multiple length scales. The last decade has seen tremendous advances in our understanding of the dynamics of protein localization and turnover at subcellular length scales, and at the other end of the spectrum, of mechanics at tissue-level length scales. Integrating the two remains a challenge, however, because we lack a detailed understanding of the subcellular patterns of mechanical properties of cells within tissues. Here, in the context of the elongating body axis of

Indexed as

Single-Cell AnalysisAnimalsBody PatterningCadherinsCell PolarityIntercellular JunctionsMorphogenesisXenopusCadherinsaxis elongationcadherincell biologyheterogeneityphysics of living systemsplanar cell polarityxenopus

Identifiers

PMID34032216
PMCPMC8205493
OpenAlexW3165299462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.