ArticleeLife2021
Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed, 52 citations in OpenAlex.
- Supraspinal Circuit Mechanisms Underlying Itch Processing.CNS neuroscience & therapeutics · 2026Review
- Long-range circuit of the mouse spinal trigeminal nucleus caudalis.The journal of headache and pain · 2026Article
- Central amygdalar PKCδ neurons mediate fentanyl withdrawal.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Respiratory-Limbic Coupling via a Thalamic Circuit Alleviates Anxiety.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Lateral hypothalamus directs stress-induced modulation of acute and psoriatic itch.Cell reports · 2026Article
- Chronic stress increases the susceptibility to chronic vulvar pain following acute vulvar inflammation in a preclinical model of vulvodynia.Molecular brain · 2026Article
- Breaking the vicious cycle: a bibliometric and visual analysis of the bidirectional relationship between pruritus and negative emotions.Frontiers in psychiatry · 2026Review
- Central neural circuits underlying itch sensation.Nature reviews. Neuroscience · 2025Review
- Cortical Control of Itch Sensation by Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Anterior Cingulate Cortex.Neuroscience bulletin · 2025Article
- Article
- Single Inhalation of Peppermint Essential Oil Alleviates Acute Restraint Stress-Exacerbated Itch in Oxazolone-Induced Mild Dermatitis: Correlations With Brain Neuronal Activity in Female BALB/c Mouse.Brain and behavior · 2025Article
- A Spinal Circuit for Modular Gating of Organ Somatosensation.bioRxiv : the preprint server for biology · 2025Article
- Article
- Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons.Acta pharmacologica Sinica · 2025Article
- Transcriptomic landscape of mammalian ventral pallidum at single-cell resolution.Science advances · 2024Article
- Cell Type-Specific Modulation of Acute Itch Processing in the Anterior Cingulate Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Activation of NPY2R-expressing amygdala neurons inhibits itch behavior in mice without lateralization.Scientific reports · 2024Article
- Cells and circuits for amygdala neuroplasticity in the transition to chronic pain.Cell reports · 2024Article
- Generation and Characterization of a NovelThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Multiple cholinergic receptor subtypes coordinate dual modulation of acetylcholine on anterior and posterior paraventricular thalamic neurons.Journal of neurochemistry · 2024Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Itch is an unpleasant sensation that elicits robust scratching and aversive experience. However, the identity of the cells and neural circuits that organize this information remains elusive. Here, we show the necessity and sufficiency of chloroquine-activated neurons in the central amygdala (CeA) for both itch sensation and associated aversion. Further, we show that chloroquine-activated CeA neurons play important roles in itch-related comorbidities, including anxiety-like behaviors, but not in some aversive and appetitive behaviors previously ascribed to CeA neurons. RNA-sequencing of chloroquine-activated CeA neurons identified several differentially expressed genes as well as potential key signaling pathways in regulating pruritis. Finally, viral tracing experiments demonstrate that these neurons send projections to the ventral periaqueductal gray that are critical in modulation of itch. These findings reveal a cellular and circuit signature of CeA neurons orchestrating behavioral and affective responses to pruritus in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.