Evidence map›Paper›PMID 34032031›Full record

ArticleJournal of Korean medical science2021

Intellectual Functioning of Pediatric Patients with Chronic Kidney Disease: Results from the KNOW-Ped CKD.

Na Ri Kang, Yo Han Ahn, Eujin Park, Keum Hwa Lee, Hee Sun Baek, Seong Heon Kim, Heeyeon Cho, Min Hyun Cho, Jae Il Shin, Joo Hoon Lee and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02165878 (KoreaN Cohort Study for Outcome in Pediatric Patients With Chronic Kidney Disease), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02165878 unknown statusnot on this map

KoreaN Cohort Study for Outcome in Pediatric Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease

TypeobservationalSponsorSeoul National University HospitalRan2011 to 2021Enrolled458ConditionsChronic Kidney Disease(CKD)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Na Ri Kang *Department of Psychiatry, College of Medicine, Jeju National University, Jeju, Korea.ORCID https://orcid.org/0000-0002-2086-0927
Yo Han Ahn *Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-8185-4408
Eujin ParkDepartment of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-4413-468X
Keum Hwa LeeDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-1511-9587
Hee Sun BaekDepartment of Pediatrics, Kyungpook National University, School of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0003-0940-360X
Seong Heon KimDepartment of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.ORCID https://orcid.org/0000-0001-8003-3010
Heeyeon ChoDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-3137-6054
Min Hyun ChoDepartment of Pediatrics, Kyungpook National University, School of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0002-7965-7587
Jae Il ShinDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-2326-1820
Joo Hoon LeeDepartment of Pediatrics, Asan Medical Center Childrens' Hospital, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8010-3605
Hae Il CheongDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-7556-1265
Hee Gyung KangDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-8323-5320
Young Seo ParkDepartment of Pediatrics, Asan Medical Center Childrens' Hospital, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7653-2036
Il Soo HaDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-5428-6209
Duk Soo MoonDepartment of Psychiatry, College of Medicine, Jeju National University, Jeju, Korea.ORCID https://orcid.org/0000-0001-7878-3410
Kyoung Hee HanDepartment of Pediatrics, College of Medicine, Jeju National University, Jeju, Korea. hansyang78@gmail.com.ORCID https://orcid.org/0000-0002-6830-7311
Jeju National University · KRKorea University Medical Center · KRKyungpook National University · KRSeoul National University · KRSeoul National University Children's Hospital · KRYonsei University · KRHallym University Kangnam Sacred Heart Hospital · KRPusan National University Yangsan Hospital · KRSamsung Medical Center · KR

Funding

Korea Disease Control and Prevention Agency 2011E3300300Korea Disease Control and Prevention Agency 2012E3301100Korea Disease Control and Prevention Agency 2013E3301600Korea Disease Control and Prevention Agency 2013E3301601Korea Disease Control and Prevention Agency 2013E3301602Korea Disease Control and Prevention Agency 2016E3300200Korea Disease Control and Prevention Agency 2016E3300201Korea Disease Control and Prevention Agency 2016E3300202Korea Disease Control and Prevention Agency 2019E320100Korea Disease Control and Prevention Agency 2019E320101Korea Disease Control and Prevention Agency 2019E320102
6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) has a negative impact on growth and development in children and is a risk factor for neurocognitive impairment; however, there is limited research on the cognitive function of children and adolescents with CKD. This study therefore aimed to investigate the mean intelligence and risk factors for low intelligence in children and adolescents with CKD.

methodsEighty-one patients with CKD under 18 years old were included in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD). Participants completed either the Wechsler Intelligence Scale for Children (6-16 years), or Wechsler Adult Intelligence Scale (> 16 years).

resultsThe mean full-scale intelligence quotient (IQ) was 91 ± 19; 24.7% of participants scored a full-scale IQ below 80. Participants with a short stature (height Z scores < -1.88), failure to thrive (weight Z scores < -1.65), more severe CKD stage (≥ IIIb), longer duration of CKD (≥ 5 years), and those who were Medicare or Medicaid beneficiaries, had significantly lower mean full-scale IQs.

conclusionOn linear regression analysis, the association between the full-scale IQ, and longer duration of CKD and growth failure, remained significant after controlling for demographic and clinical variables. It is therefore necessary to investigate cognitive impairment in pediatric patients with CKD who exhibit growth failure or for a longer postmorbid period. It is believed that early interventions, such as kidney transplantation, will have a positive effect on IQ in children with CKD, as the disease negatively affects IQ due to poor glomerular filtration rate over time.

trial registrationClinicalTrials.gov Identifier: NCT02165878.

Indexed as

IntelligenceQuality of LifeAdolescentChildChild, PreschoolCognitionCognition DisordersCohort StudiesCross-Sectional StudiesFemaleGlomerular Filtration RateHumansIntelligence TestsMaleRenal Insufficiency, ChronicChildrenChronic Kidney DiseaseIntelligence

Identifiers

PMID34032031
PMCPMC8144594
OpenAlexW3159682086

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.