Evidence map›Paper›PMID 34032024›Full record

ReviewMolecular oral microbiology2021

The RagA and RagB proteins of Porphyromonas gingivalis.

Jan Potempa, Mariusz Madej, David A Scott

Open access · greenAbstract readReview
In one paragraph

Review in Molecular oral microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Exploring the Genetic and Functional Diversity ofInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Review
  6. Prevalence and Phylogenetic Analysis of Lipoprotein-GeneAntibiotics (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. [Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jan PotempaDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, Kentucky, USA.
Mariusz MadejFaculty of Biochemistry, Biophysics and Biotechnology, Department of Microbiology, Jagiellonian University, Kraków, Poland.
David A ScottDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, Kentucky, USA.ORCID 0000-0003-1007-2756
Jagiellonian University · PLUniversity of Louisville · US

Funding

Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative IntravaginalP20GM125504 · NIGMS · UNIVERSITY OF LOUISVILLE · PI Shirin Ghods · 2018 to 2026
$24.4M
Bacterial peptidylarginine deiminase, a link between gums and joint diseaseR01DE022597 · NIDCR · UNIVERSITY OF LOUISVILLE · PI POTEMPA, JAN S · 2013 to 2023
$3.7M
P. gingivalis genes essential for tobacco smoke survivalR01DE026963 · NIDCR · UNIVERSITY OF LOUISVILLE · PI SCOTT, DAVID A · 2017 to 2024
$2.5M
Filifactor alocis-tobacco interactionsR21DE028506 · NIDCR · UNIVERSITY OF LOUISVILLE · PI SCOTT, DAVID A · 2020 to 2021
$429k
NIDCR NIH HHS R01 DE022597NIDCR NIH HHS R01 DE026963NIDCR NIH HHS R21 DE028506NIGMS NIH HHS P20 GM125504
6 · The paper itself

Abstract

RagA and RagB proteins are major components of the outer membrane of the oral pathogen Porphyromonas gingivalis and, while recently suggested to represent a novel peptide uptake system, their full function is still under investigation. Herein, we (a) discuss the evidence that the rag locus contributes to P. gingivalis virulence; (b) provide insight to Rag protein potential biological function in macromolecular transport and other aspects of bacterial physiology; (c) address the host response to Rag proteins which are immunodominant and immunomodulatory; and (d) review the potential of Rag-focused therapeutic strategies for the control of periodontal diseases.

Indexed as

Periodontal DiseasesPorphyromonas gingivalisBacterial ProteinsHumansVirulenceBacterial Proteinsperiodontal diseasessporphyromonasRagABstructure functionvirulence

Identifiers

PMID34032024
PMCPMC8349833
OpenAlexW3165870708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.