Observational studyDiabetic medicine : a journal of the British Diabetic Association2021
Prediabetes is associated with proteinuria development but not with glomerular filtration rate decline: A longitudinal observational study.
Observational study in Diabetic medicine : a journal of the British Diabetic Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Association between prediabetes and nephropathy: a comprehensive systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Prediabetes and the risk of incident chronic kidney disease in adults: A systematic review and meta-analysis.Biomolecules & biomedicine · 2026Pooled it
- Prevalence and factors linked to renal involvement in prediabetes patients across Europe in the ePREDICE trial.Scientific reports · 2024Trial
- Modified cut-off value of the urine albumin-to-creatinine ratio is helpful for identifying patients at high risk for chronic kidney disease in prediabetes.Acta diabetologica · 2026Article
- Proteinuria and the risk of Incident atrial fibrillation according to glycemic stages: a nationwide population-based cohort study.Cardiovascular diabetology · 2025Article
- Kidney function trajectories, associated factors, and outcomes in multiethnic Asian patients with type 2 diabetes.Journal of diabetes · 2024Article
- Incident Proteinuria by HIV Serostatus Among Men With Pre--Diabetes Mellitus: The Multicenter AIDS Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Pros and cons of live kidney donation in prediabetics: A critical review and way forward.World journal of transplantation · 2024Review
- Association of estimated glomerular filtration rate and incident pre-diabetes: A secondary 5-year longitudinal cohort study in Chinese people.Frontiers in endocrinology · 2022Article
- Impact of Glucose Tolerance and Its Change on Incident Proteinuria: Analysis of a Nationwide Population-Based Dataset.American journal of nephrology · 2022Article
- Prediabetes is associated with proteinuria development but not with glomerular filtration rate decline: A longitudinal observational study.Diabetic medicine : a journal of the British Diabetic Association · 2021Observational
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsDiabetes is recognized as the leading cause of chronic kidney disease (CKD); however, the association of prediabetes with CKD remains unclear, in particular, the independent effect of prediabetes on proteinuria or estimated glomerular filtration rate (eGFR) has not been evaluated. This study aimed to investigate the associations of prediabetes with the proteinuria development and with eGFR decline separately in the Japanese general population without CKD.
methodsParticipants who underwent health check-ups in 2014 and had adequate data after 2 years were retrospectively analysed. A total of 405,487 participants without CKD (eGFR, ≥60 ml min
resultsAfter 2 years, 7037 participants (1.7%) developed proteinuria alone, 19,015 (4.7%) presented eGFR decline alone and 636 (0.2%) showed both proteinuria and eGFR decline. Compared to normal glucose level and adjusting for prognostic factors, prediabetes was independently associated with the proteinuria development (odds ratio [OR] 1.233; 95% confidence interval [CI] 1.170-1.301], whereas prediabetes was not associated with eGFR decline (OR 0.981; 95% CI 0.947-1.017).
conclusionsPrediabetes is associated with the proteinuria development but not with eGFR decline in the general population.
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