ArticleCardiology journal2021
Long-term antibiotic therapy in patients with surgery-indicated not undergoing surgery infective endocarditis.
Article in Cardiology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Safety and Efficacy of Outpatient Parenteral Antibiotic Therapy (OPAT) in Patients With Infective Endocarditis: A Systematic Review and Meta-Analysis.Clinical cardiology · 2025Pooled it
- Long-term Oral Suppressive Antimicrobial Therapy in Infective Endocarditis (SATIE Study): An Observational Study.Open forum infectious diseases · 2024Trial
- Percutaneous Mechanical Aspiration of Left-Sided Intracardiac Masses for Prohibitive Surgical Candidates: A Single-Center Experience.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Infective Endocarditis in Perceval Sutureless Valves: Incidence, Diagnostic Challenges, and Management: An Expert Opinion Review.Diagnostics (Basel, Switzerland) · 2026Review
- Outcomes of Prosthetic Valve Endocarditis Managed by a Multidisciplinary Endocarditis Team: A Retrospective Cohort Study.CJC open · 2026Article
- Evolution of Management and Outcomes of Infective Endocarditis After Introducing the Endocarditis Team.JACC. Advances · 2026Article
- Lactococcus garvieae prosthetic aortic and mitral valve endocarditis with multiple embolic complications: a case report.Access microbiology · 2026Article
- ENDOCOR: a nationwide consortium of endocarditis teams-initiating a registry for infective endocarditis within the Netherlands Heart Registration.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2025Article
- Successful fluoroquinolone-based salvage therapy in the conservative management of refractory infective endocarditis caused byOxford medical case reports · 2025Article
- Infective endocarditis: it takes a team.European heart journal · 2025Review
- Halfway between Cure and Care: Suppressive Therapy in Inoperable Infective Endocarditis.Le infezioni in medicina · 2025Article
- From flank pain to splenic abscess: a complex case of infective endocarditis with literature review.BMC cardiovascular disorders · 2024Review
- Article
- Dalbavancin as consolidation therapy for infective endocarditis in patients with comorbidity. A real world experience.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024Observational
- Contemporary Role of Positron Emission Tomography (PET) in Endocarditis: A Narrative Review.Journal of clinical medicine · 2024Review
- Enterococcal endocarditis management and relapses.JAC-antimicrobial resistance · 2024Article
- Review
Corrections and comments
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Authors and funding
24 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, there is little information regarding management of patients with infective endocarditis (IE) that did not undergo an indicated surgery. Therefore, we aimed to evaluate prognosis of these patients treated with a long-term antibiotic treatment strategy, including oral long term suppressive antibiotic treatment in five referral centres with a multidisciplinary endocarditis team.
methodsThis retrospective, multicenter study retrieved individual patient-level data from five referral centres in Spain. Among a total of 1797, 32 consecutive patients with IE were examined (median age 72 years; 78% males) who had not undergone an indicated surgery, but received long-term antibiotic treatment (LTAT) and were followed by a multidisciplinary endocarditis team, between 2011 and 2019. Primary outcomes were infection relapse and mortality during follow-up.
resultsAmong 32 patients, 21 had IE associated with prostheses. Of the latter, 8 had an ascending aorta prosthetic graft. In 24 patients, a switch to long-term oral suppressive antibiotic treatment (LOSAT) was considered. The median duration of LOSAT was 277 days. Four patients experienced a relapse during follow-up. One patient died within 60 days, and 12 patients died between 60 days and 3 years. However, only 4 deaths were related to IE.
conclusionsThe present study results suggest that a LTAT strategy, including LOSAT, might be considered for patients with IE that cannot undergo an indicated surgery. After hospitalization, they should be followed by a multidisciplinary endocarditis team.
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