Evidence map›Paper›PMID 34031847›Full record

Observational studyJournal of nephrology2021

Assessing accuracy of estimated dry weight in dialysis patients post transplantation: the kidney knows best.

Michael J Germain, Barbara A Greco, Spencer Hodgins, Bikash Chapagain, Ravi Thadhani, David Wojciechowski, Kerry Crisalli, Brian H Nathanson, Yossi Chait

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Remote Measurement of Volume Status in Heart Failure.Journal of the American Society of Nephrology : JASN · 2025
    Review
  3. Review
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Michael J GermainRenal and Transplant Associates of New England, PC, Springfield, MA, 01107, USA.
Barbara A GrecoRenal and Transplant Associates of New England, PC, Springfield, MA, 01107, USA.
Spencer HodginsKidney Care and Transplant Service of New England, Springfield, MA, 01104, USA.
Bikash ChapagainMidState Nephrology Associates, 85 Church St, Middletown, CT, 06457, USA.
Ravi ThadhaniMassachusetts General Brigham, Boston, MA, 02199, USA.
David WojciechowskiUniversity of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Kerry CrisalliMassachusetts General Hospital, Boston, MA, 02114, USA.
Brian H NathansonOptiStatim, LLC, Longmeadow, MA, 01106, USA.
Yossi ChaitUniversity of Massachusetts, Amherst, MA, 01106, USA. ychait@umass.edu.ORCID http://orcid.org/0000-0002-6581-8124
Baystate Medical Center · USKidney Associates · USMassachusetts General Hospital · USMidstate Medical Center · USOptim Design (United States) · USThe University of Texas Southwestern Medical Center · USUniversity of Massachusetts Amherst · US

Funding

The Engineering of Individualized Anemia Management ProtocolsK25DK096006 · NIDDK · UNIVERSITY OF MASSACHUSETTS AMHERST · PI CHAIT, YOSSI · 2013 to 2016
$670k
NIDDK NIH HHS DK096006NIDDK NIH HHS K25 DK096006
6 · The paper itself

Abstract

introductionEstimated dry weight is used to guide fluid removal during outpatient hemodialysis sessions. Errors in estimated dry weight can result in intradialytic hypotension and interdialytic fluid overload. The goal of this study was to assess the accuracy of estimated dry weight by comparing it to the 2-week post-transplant weight in two cohorts of hemodialysis patients.

methodsThis observational, multi-center, retrospective cohort study included maintenance hemodialysis patients who underwent kidney transplantation at two medical centers in Massachusetts. The relationship between estimated dry weight pre-transplant and weight at week 2 post-transplant in patients with good allograft function (serum creatinine ≤ 1.5 mg/dL) was analyzed. Estimated dry weight was considered accurate if it was within ± 2% of the week 2 post-transplant weight.

resultsFifty seven patients with good allograft function were identified: mean age 54 ± 14 years, 32 (58%) from deceased donors, 22 (38.6%) females. 38 were Caucasian (66.7%), 11 Hispanic (19.3%), 3 black (5.3%), and 5 others (8.8%). 2-week mean post transplantation serum creatinine was 1.2 ± 0.2 mg/dL. Mean (SD) estimated dry weight was 71.4 ± 15.9. Before transplantation, only 14 (24.6%) patients were within ± 2% of the 2-week post-transplant weight; 23 (40.3%) were above and 20 (35.1%) were below.

conclusionsOur point of view, based on the assumption that the weight of patients with good allograft function at 2 weeks post-transplant approaches their accurate dry weight, is that a majority of maintenance hemodialysis patients (75.4%) are hypervolemic or hypovolemic prior to renal transplantation. This highlights the importance of finding novel tools to achieve euvolemia in patients undertaking dialysis. Timely feedback regarding achieved weight 2 weeks post-transplant to treating nephrologists and dialysis centers may be a starting point for assessing accuracy of dry weight.

Indexed as

Kidney Failure, ChronicKidney TransplantationAdultAgedFemaleHumansKidneyMiddle AgedRenal DialysisRetrospective StudiesDry weightMaintenance hemodialysis

Identifiers

PMID34031847
PMCPMC8611116
OpenAlexW3165299504

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.