Evidence map›Paper›PMID 34031668›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Distinct Mucoinflammatory Phenotype and the Immunomodulatory Long Noncoding Transcripts Associated with SARS-CoV-2 Airway Infection.

Dinesh Devadoss, Arpan Acharya, Marko Manevski, Kabita Pandey, Glen M Borchert, Madhavan Nair, Mehdi Mirsaeidi, Siddappa N Byrareddy, Hitendra S Chand

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Dinesh Devadoss
Arpan Acharya
Marko Manevski
Kabita Pandey
Glen M Borchert
Madhavan Nair
Siddappa N Byrareddy
Florida International University · USUniversity of Nebraska Medical Center · USUniversity of Miami · USUniversity of South Alabama · US

Funding

Neuroimmunology of Disease Training ProgramT32NS105594 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Aditya N Bade, Howard E Gendelman · 2018 to 2026
$1.4M
Novel long noncoding RNAs in the airway mucous responseR21AI144374 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI LAKSHMANA, MADEPALLI KRISHNAPPA · 2019 to 2020
$625k
LncRNA in Alzheimer's Disease-Associated Neuroinflammation and NeurodegenerationR21AI152937 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI LAKSHMANA, MADEPALLI KRISHNAPPA · 2020 to 2021
$597k
NIAID NIH HHS R21 AI144374NIAID NIH HHS R21 AI152937NINDS NIH HHS T32 NS105594
6 · The paper itself

Abstract

Respiratory epithelial cells are the primary target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated the 3D human airway tissue model to evaluate innate epithelial cell responses to SARS-CoV-2 infection. A SARS-CoV-2 clinical isolate productively infected the 3D-airway model with a time-dependent increase in viral load (VL) and concurrent upregulation of airway immunomodulatory factors (

Identifiers

PMID34031668
PMCPMC8142670
OpenAlexW3162190930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.