Evidence map›Paper›PMID 34031604›Full record

ArticleNature medicine2021

Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis.

Sebastian M Gygli, Chloé Loiseau, Levan Jugheli, Natia Adamia, Andrej Trauner, Miriam Reinhard, Amanda Ross, Sonia Borrell, Rusudan Aspindzelashvili, Nino Maghradze and 5 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Within-host evolution of drug tolerance inJAC-antimicrobial resistance · 2026
    Article
  7. Article
  8. Variability in intrinsic drug tolerance inAntimicrobial agents and chemotherapy · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Transmission ofEpidemiology and infection · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Sebastian M Gygli *Swiss Tropical and Public Health Institute, Basel, Switzerland.
Chloé Loiseau *Swiss Tropical and Public Health Institute, Basel, Switzerland.
Levan JugheliSwiss Tropical and Public Health Institute, Basel, Switzerland.
Natia AdamiaNational Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.
Andrej TraunerSwiss Tropical and Public Health Institute, Basel, Switzerland.ORCID http://orcid.org/0000-0002-6260-9829
Miriam ReinhardSwiss Tropical and Public Health Institute, Basel, Switzerland.
Amanda RossSwiss Tropical and Public Health Institute, Basel, Switzerland.ORCID http://orcid.org/0000-0001-6027-5645
Sonia BorrellSwiss Tropical and Public Health Institute, Basel, Switzerland.
Rusudan AspindzelashviliNational Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.
Nino MaghradzeSwiss Tropical and Public Health Institute, Basel, Switzerland.
Klaus ReitherSwiss Tropical and Public Health Institute, Basel, Switzerland.
Christian BeiselDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.ORCID http://orcid.org/0000-0001-5360-2193
Nestani TukvadzeSwiss Tropical and Public Health Institute, Basel, Switzerland.
Zaza AvalianiNational Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.
Sebastien GagneuxSwiss Tropical and Public Health Institute, Basel, Switzerland. sebastien.gagneux@swisstph.ch.ORCID http://orcid.org/0000-0001-7783-9048
Swiss Tropical and Public Health Institute · CHNational Center for Tuberculosis and Lung Disease · GEETH Zurich · CH

Funding

Emory-Georgia TB Research Training ProgramD43TW007124 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Nestani Tukvadze · 2004 to 2026
$4.6M
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 309540-EVODRTBEC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 883582-ECOEVODRTBFIC NIH HHS D43 TW007124Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_188888Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) CRSII5_177163Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) IZLSZ3_170834Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) IZRJZ3_164171
6 · The paper itself

Abstract

Multidrug-resistant tuberculosis (MDR-TB) accounts for one third of the annual deaths due to antimicrobial resistance

Indexed as

PrisonsAntitubercular AgentsDrug Resistance, Multiple, BacterialHumansMutationMycobacterium tuberculosisPrisonersTuberculosis, Multidrug-ResistantAntitubercular Agents

Identifiers

PMID34031604
PMCPMC9400913
OpenAlexW3165693406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.