Evidence map›Paper›PMID 34031570›Full record

ArticlePediatric research2021

Juvenile idiopathic arthritis: lymphocyte activation gene-3 is a central immune receptor in children with oligoarticular subtypes.

Erdal Sag, Selcan Demir, Maithri Aspari, Morten Aagaard Nielsen, Cæcilie Skejø, Malene Hvid, Egemen Turhan, Yelda Bilginer, Stinne Greisen, Seza Ozen and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Exploring new frontiers in LAG-3 biology and therapeutics.Trends in pharmacological sciences · 2025
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Erdal SagDepartment of Biomedicine, Aarhus University, Aarhus, Denmark. sag.erdal@gmail.com.
Selcan DemirDivision of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey.
Maithri AspariDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Morten Aagaard NielsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Cæcilie SkejøDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Malene HvidDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Egemen TurhanDepartment of Orthopedics and Traumatology, Hacettepe University, Ankara, Turkey.
Yelda BilginerDivision of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey.
Stinne GreisenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Seza OzenDivision of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey.
Bent DeleuranDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Aarhus University · DKHacettepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the role of inhibitory receptors (IRs) and especially lymphocyte activation gene-3 (LAG-3) in the pathogenesis of oligoarticular juvenile idiopathic arthritis (o-JIA).

methodsPaired samples of synovial fluid (SF) and plasma and peripheral blood (PBMCs) and synovial fluid mononuclear cells (SFMCs) were collected from o-JIA patients along with their clinical data (n = 24). Plasma from healthy controls (n = 14) and paired SF and plasma samples from five non-arthritic juvenile orthopedic patients (n = 5) served as controls. Spontaneously differentiated fibroblast-like synoviocytes (FLSs) from SFMCs were co-cultured with autologous PBMCs/SFMCs and used as ex vivo disease model. Soluble levels and cellular expressions of IRs together with their functional properties in the ex vivo model were analyzed.

resultsIn patients with o-JIA, soluble levels of LAG-3 and expression of LAG-3 and T cell immunoglobulin mucin03 (TIM-3) on CD3

conclusionsThis is the first report comparing the effects of different IRs in o-JIA and suggests that LAG-3 might contribute to the pathogenesis of this disease. IMPACT: This is the first study addressing the role of different co-IRs in o-JIA. We showed that LAG-3 and TIM-3 seem more important in juvenile arthritis in contrast to adult rheumatoid arthritis, where cytotoxic T-lymphocyte-associated antigen-4 and programmed cell death-1 were reported to be more important. We designed an ex vivo disease model for o-JIA, examined the effects of co-IRs in this model, and demonstrated that they might contribute to the pathogenesis of the disease. LAG-3 might play a role in o-JIA pathogenesis and might be a potential therapeutic option for o-JIA patients.

Indexed as

Antigens, CDArthritis, JuvenileChildHumansJoint DiseasesLymphocyte Activation Gene 3 ProteinReceptors, ImmunologicT-LymphocytesAntigens, CDLag3 protein, humanLymphocyte Activation Gene 3 ProteinReceptors, Immunologic

Identifiers

PMID34031570
OpenAlexW3164706924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.