ArticleNature plants2021
Coordination of microbe-host homeostasis by crosstalk with plant innate immunity.
Article in Nature plants, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 1 synthesis or guideline pooled it, 223 citations in OpenAlex.
- Root colonization by beneficial rhizobacteria.FEMS microbiology reviews · 2024Pooled it
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- Variations in Soil Microbiome Assembly Determine Hatching Induction of the Carrot Cyst Nematode Heterodera carotae.Environmental microbiology · 2026Article
- Systems-Level Plant Responses Reveal Pseudomonas-Mediated Growth Promotion in Brachypodium Under Nitrogen Limitation.Plant, cell & environment · 2026Article
- The Mitogen-Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis-Immunity Trade-Off in Cotton by Regulating Salicylic Acid Biosynthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Light-Root Microbiome Interactions in Vegetable Crops: From Photoreceptor Signaling to Exudate-Mediated Recruitment.International journal of molecular sciences · 2026Review
- The metabolic and anatomical complexity of root microhabitats modulate their interaction with the microbiota.Nature communications · 2026Article
- Synthetic communities and metabolite-driven enrichment of keystone rhizosphere microbial taxa suppress bacterial wilt disease in peanut.Plant communications · 2026Article
- Seed-borne bacteria-mediated seedling microbiome assembly: genetic and metabolic mechanisms of salt tolerance.Archives of microbiology · 2026Review
- Synthetic microbial communities: from theoretical exploration to applied innovation.World journal of microbiology & biotechnology · 2026Review
- Early seed priming with closely relatedHorticulture research · 2026Article
- A Specific Sinorhizobium Flagellin Suppresses Legume Nodulation Through Immune Activation.Plant biotechnology journal · 2026Article
- Artificial soil (ArtSoil): Recreating soil conditions in synthetic plant growth media.The Plant journal : for cell and molecular biology · 2026Article
- Functional Portability of a Hyperaccumulator-Derived Core Microbiome: Enhancing Cadmium Phytoextraction inToxics · 2026Article
- Nitrogen-Controlled Host Gatekeeping: Regulatory Chokepoints Across Four Windows for Diazotroph Access.International journal of molecular sciences · 2026Article
- RHD6LA regulates root hair responses to both symbionts and commensals.Nature communications · 2026Article
- Compartment-Specific Niche Filtering Shapes the Structure and Nutrient-Cycling Potential of Bacterial Communities in Eutrophic Waters withPlants (Basel, Switzerland) · 2026Article
- Upregulated jasmonate signaling shifts Arabidopsis microbiota interactions and stress adaptations through a positive feedback loop.The ISME journal · 2026Article
- Enrichment is not necessarily recruitment in root microbiome assembly.The ISME journal · 2026Review
- Synthetic bacterial community colonizes wheat roots grown in soil and mimics the assembly pattern of a field community in a cultivar dependent manner.ISME communications · 2026Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants grown in natural soil are colonized by phylogenetically structured communities of microbes known as the microbiota. Individual microbes can activate microbe-associated molecular pattern (MAMP)-triggered immunity (MTI), which limits pathogen proliferation but curtails plant growth, a phenomenon known as the growth-defence trade-off. Here, we report that, in monoassociations, 41% (62 out of 151) of taxonomically diverse root bacterial commensals suppress Arabidopsis thaliana root growth inhibition (RGI) triggered by immune-stimulating MAMPs or damage-associated molecular patterns. Amplicon sequencing of bacterial 16S rRNA genes reveals that immune activation alters the profile of synthetic communities (SynComs) comprising RGI-non-suppressive strains, whereas the presence of RGI-suppressive strains attenuates this effect. Root colonization by SynComs with different complexities and RGI-suppressive activities alters the expression of 174 core host genes, with functions related to root development and nutrient transport. Furthermore, RGI-suppressive SynComs specifically downregulate a subset of immune-related genes. Precolonization of plants with RGI-suppressive SynComs, or mutation of one commensal-downregulated transcription factor, MYB15, renders the plants more susceptible to opportunistic Pseudomonas pathogens. Our results suggest that RGI-non-suppressive and RGI-suppressive root commensals modulate host susceptibility to pathogens by either eliciting or dampening MTI responses, respectively. This interplay buffers the plant immune system against pathogen perturbation and defence-associated growth inhibition, ultimately leading to commensal-host homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.