ArticleScientific reports2021
A validated model for predicting live birth after embryo transfer.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The development of nomograms to predict multiple pregnancy and multiple birth in frozen- thawed embryo transfer cycles: a retrospective study.Frontiers in endocrinology · 2026Article
- Multidimensional trophoblast invasion assessment by combining 3D in vitro modeling and deep learning analysis.NPJ systems biology and applications · 2025Article
- Predictive model for live birth outcomes in single euploid frozen embryo transfers: a comparative analysis of logistic regression and machine learning approaches.Journal of assisted reproduction and genetics · 2025Article
- Study Protocol: Evaluating the Effectiveness of Variable Embryo Transfer Compared to Endometrial Receptivity Analysis in Improving Implantation and Pregnancy Outcomes in Patients with Recurrent Implantation Failure.Journal of pharmacy & bioallied sciences · 2025Article
- Comparison of ART outcome in patients with poor ovarian response according to POSEIDON criteria.Scientific reports · 2022Observational
- Embryo morphology and live birth in the United States.F&S reports · 2022Article
- A validated model for predicting live birth after embryo transfer.Scientific reports · 2021Article
- Transfer Strategy Minimizing Twin Risk of Double Blastocyst Transfers Based on Prediction Models.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurately predicting the probability of live birth and multiple gestations is important for determining a safe number of embryos to transfer after in vitro fertilization. We developed a model that can be fit to individual clinic data for predicting singleton, twin, and total live birth rates after human embryo transfer. The predicted and observed rates of singleton and twin deliveries were compared in a tenfold cross-validation study using data from a single clinic. The model presented accounts for patient age, embryo stage (cleavage or blastocyst), type of transfer cycle (fresh or frozen) and uterine/universal factors. The standardized errors for rates of singleton and twin deliveries were normally distributed and the mean errors were not significantly different from zero (all p > 0.05). The live birth rates per embryo varied from as high as 43% for fresh blastocysts in the 35-year-old age group to as low as 1% for frozen cleavage stage embryos in the 43-year-old age group. This quantitative model or a simplified version can be used for clinics to generate and analyze their own data to guide the number of embryos to transfer to limit the risk of multiple gestations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.