Evidence map›Paper›PMID 34031374›Full record

ArticleNature communications2021

Microsecond fingerprint stimulated Raman spectroscopic imaging by ultrafast tuning and spatial-spectral learning.

Haonan Lin, Hyeon Jeong Lee, Nathan Tague, Jean-Baptiste Lugagne, Cheng Zong, Fengyuan Deng, Jonghyeon Shin, Lei Tian, Wilson Wong, Mary J Dunlop and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
23.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 133 citations in OpenAlex.

  1. PLANCK: super-multiplex optical imaging without labeling.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review of methods for the determination of cellular cholesterol content: principles, advantages, limitations, applications, and perspectives.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Haonan LinDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.ORCID 0000-0003-0437-5902
Hyeon Jeong LeePhotonics Center, Boston University, Boston, MA, USA.ORCID 0000-0002-2417-9338
Nathan TagueDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Jean-Baptiste LugagneDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.ORCID 0000-0002-8374-6590
Cheng ZongPhotonics Center, Boston University, Boston, MA, USA.
Fengyuan DengPhotonics Center, Boston University, Boston, MA, USA.
Jonghyeon ShinDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Lei TianDepartment of Electrical and Computer Engineering, Boston University, Boston, MA, USA.ORCID 0000-0002-1316-4456
Wilson WongDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.ORCID 0000-0001-8394-889X
Mary J DunlopDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.ORCID 0000-0002-9261-8216
Ji-Xin ChengDepartment of Biomedical Engineering, Boston University, Boston, MA, USA. jxcheng@bu.edu.ORCID 0000-0002-5607-6683
Boston University · US

Funding

Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living SystemsR35GM136223 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2020 to 2025
$5.7M
Rapid AST through Metabolic Imaging at Single Cell LevelR01AI141439 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Ji-Xin Cheng · 2019 to 2026
$4.7M
High-content High-speed Chemical Imaging of Metabolic Reprogramming by Integration of Advanced Instrumentation and Data ScienceR01EB032391 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2022 to 2025
$2.0M
High-throughput high-content single cell analysis by multichannel stimulatedRaman flow cytometryR01GM118471 · NIGMS · PURDUE UNIVERSITY · PI CHENG, JI-XIN · 2016 to 2019
$1.6M
Quantitative SRS Imaging of Cancer Metabolism at Single Cell LevelR33CA223581 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2018 to 2020
$1.1M
NCI NIH HHS R33 CA223581NIAID NIH HHS R01 AI141439NIBIB NIH HHS R01 EB032391NIGMS NIH HHS R01 GM118471NIGMS NIH HHS R35 GM136223
6 · The paper itself

Abstract

Label-free vibrational imaging by stimulated Raman scattering (SRS) provides unprecedented insight into real-time chemical distributions. Specifically, SRS in the fingerprint region (400-1800 cm

Indexed as

AnimalsBiofuelsBrainCell LineCell Line, TumorLipid MetabolismMiceMicrobiological TechniquesOptical ImagingSpectrum Analysis, RamanVibrationBiofuels

Identifiers

PMID34031374
PMCPMC8144602
OpenAlexW3165513143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.